摘要
自噬是真核细胞中高度保守的一种亚细胞降解途径。该途径中,一些损坏、标记的大分子物质(如蛋白质等)或细胞器被自噬体包裹后送入溶酶体(动物)或液泡(酵母和植物)中降解并重新利用。长期以来,人们认为自噬在降解大量的细胞质成分时是一种非选择性的过程。然而,最近几年的研究结果表明,无论是酵母还是高等的真核生物细胞中均存在许多类型的选择性自噬。该研究主要综述了近几年选择性自噬过程与分子机制的研究进展。
Autophagy is a cellular degradation pathway which is highly conserved in eukaryotic cells.Generally,some damaged macromolecules or organelles were wrapped by autophagosomes which will fuse with lysosome （animal） or vacuole （yeast and plant） for degrading and recycling.For a long time,people think that autophagy is a non-selective process.In recent years,many researchs show that there are many types of selective autophagy in yeast and higher eukaryotic cells.This paper mainly reviews the molecular mechanism and process in selectiveautophagy in recent years.
出处
《安徽农业科学》
CAS
2014年第25期8488-8491,共4页
Journal of Anhui Agricultural Sciences
基金
高校学术带头人和优秀人才扶持基金(XT412002)
