摘要
隐丹参酮(cryptotanshinone,CPT)作为活血化瘀药丹参脂溶性成分中的代表性成分,其在心血管疾病、抗肿瘤及神经退行性疾病等方面显示出很好的前景,使其逐渐成为人们关注的对象。大量实验与临床研究证明,CPT主要通过抑制肿瘤细胞增殖、诱导肿瘤细胞凋亡、抑制血管生成及抑制肿瘤细胞的侵袭黏附,从而在一定程度上阻碍肿瘤细胞侵袭和防止其向远处转移。该文主要对CPT抗肿瘤转移作用的研究进展做一综述。
Cryptotanshinone （CPT）is a major fat-soluble ingre-dient in Salvia,which is a traditional blood-activating and stasis-dissolving drug.CPT has been gradually concerned,because it has a remarkable therapeutic effect on cardiovascular diseases, cancer and neurodegenerative diseases.A large number of exper-imental and clinical studies have shown that CPT can primarily＆amp;nbsp;inhibit tumor cell′s proliferation,angiogenesis,invasion and ad-hesion and induce apoptosis.Thus to some extent,it hinders in-vasion of tumor cell and prevents the distant metastasis.This pa-per focuses on the anti-tumor metastasis of CPT.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2014年第7期893-896,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 81273647)
福建省自然科学基金项目(No 2013J01365
2012J01317)
关键词
隐丹参酮
肿瘤转移
整合素
凋亡
抑制增殖
侵袭
cryptotanshinone
tumor metastasis
integrin
ap-optosis
proliferation inhibition
invasion
