摘要
目的研究双氢杨梅树皮素(DHM)对人胃癌SGC-7901细胞端粒酶活性的影响。方法应用酶联免疫分析法检测端粒酶活性。结果双氢杨梅树皮素(6.7~10μg·mL^-1,48h)能抑制人胃癌SGC-7901细胞端粒酶活性。结论双氢杨梅树皮素抑制SGC-7901细胞增殖的作用机制可能与对端粒酶活性的抑制作用有关。
OBJECTIVE To study the influence of Dihydromyricetin (DHM) on telomerase activity of human gastriccancer SGC-7901 ceils in vitro. METHODS The telomerase activity of human gastriccancer SGC-7901 cells was determined by ELISA. RESULTS DHM (6. 7 - 10μg · mL^-1 ,48 h) inhibited telomerase activity of human gastriccancer SGC-7901 ceils. CONCLUSION The action mechanism of DHM that inhibited the proliferation of SGC-7901 ceils may relate to down-regulation the activity of telomerase of human gastriccancer SGC-7901 cells.
出处
《海峡药学》
2014年第7期168-169,共2页
Strait Pharmaceutical Journal
基金
广西中医药大学校级课题(No.P2009025)
关键词
藤茶
双氢杨梅树皮素
SGC-7901细胞
端粒酶
Ampelopsis grossedentata ( Hand. -Mazz. ) W. T. Wang
Dihydromyricetin (DHM)
SGC-7901 cells
Telomerase