摘要
目的了解带状疱疹患者T淋巴细胞亚群变化情况。方法采用流式细胞仪技术检测197例带状疱疹患者T淋巴细胞亚群的分布情况。结果与健康对照比较,带状疱疹患者外周血CD+3T淋巴细胞和CD+4T淋巴细胞明显降低,CD+8T淋巴细胞升高,CD+4/CD+8比值下降,差异均有统计学意义(P<0.05),老年带状疱疹患者下降更为明显;不同年龄组的患者间存在CD+4T淋巴细胞、CD+8T淋巴细胞、CD+4/CD+8比值的差异;不同性别组、不同视觉模拟评分组患者之间T淋巴细胞亚群值差异无统计学意义(P>0.05)。结论带状疱疹患者T淋巴细胞免疫功能下降,T淋巴细胞免疫功能下降可能与带状疱疹的发病有关。
Objective To study the changes of T lymphocyte subsets in patients with herpes zoster .Methods T lymphocyte subsets were detected by fluorescence -activated cell sorter in 197 cases with herpes zoster ,and 31 healthy volunteers recruited as control group .Re-sults CD3 ＋,CD4 ＋T cell and CD4 ＋/CD8 ＋T cell ration were significantly decreased in patients with herpes zoster ,especially in old pa-tients compared with those in control group , while CD8 ＋T cell increased obviously .There was no significant difference in CD 4 ＋, CD8 ＋T cell,CD4 ＋/CD8 ＋T cell ration of different ages ,gender and visual analogue scale score groups .Conclusion T cellular immunity function is decreased in the patients with herpes zostor .The decline of T cell immune function may be related to the pathogenesis of herpes zoster .
出处
《安徽医学》
2014年第4期485-487,共3页
Anhui Medical Journal
