摘要
目的探讨哮喘患儿诱导痰样T淋巴细胞亚群的变化。方法 以12例健康儿童为对照,39例支气管哮喘患儿分为急性发作组(n=18)及缓解期组(n=21)。采用流式细胞仪,评价诱导痰样中CD4+及CD8+T淋巴细胞百分比及CD4+/CD8+比值的变化。结果与缓解期组及正常对照组相比,急性发作组支气管诱导痰样中CD4+T淋巴细胞百分比升高,CD8+T淋巴细胞百分比降低,CD4+/CD8+比值增高(P<0.05);缓解期组和正常对照组上述三项指标的组间差异无统计学意义(P>0.05)。结论哮喘患儿急性发作期诱导痰样中CD4+T淋巴细胞占优势,CD4+/CD8+T淋巴细胞比例失衡。
Objective To observe the alteration of T-lymphocyte subsets of induced sputum in children with asthma.Methods Thirty-nine children with asthma were divided into acute episode group（n=18） and remission group（n=21）,and twelve healthy children were enrolled as control group.The percentage of CD4＋ and CD8＋ T-lymphocytes and the ratio of CD4＋ /CD8＋ in three groups were detected using flow cytometry.Results Compared with remission group and control group,the percentage of CD4＋ T-lymphocytes increased and CD8＋ T-lymphocytes decreased in acute episode group（P〈0.05）.The ratio of CD4＋/CD8＋ increased in acute episode group also（P〈0.05）.There were no significant differences in the percentage of CD4＋ and CD8＋ T-lymphocytes and the ratio of CD4＋/CD8＋ between remission group and control group（P〉0.05）.Conclusion CD4＋ T-lymphocyte is the predominant subset of T-lymhpocytes and the ratio of CD4＋/CD8＋ is imbalance in sputum induced from children with acute asthma.
出处
《世界临床药物》
CAS
2010年第12期733-735,共3页
World Clinical Drug
