摘要
目的:评价温脾补肾法对中晚期恶性肿瘤患者免疫功能调节的疗效。方法:选取明确诊断的中晚期恶性肿瘤患者,随机分为对照组和治疗组,对照组采用常规治疗方案,治疗组在此基础上联合温脾补肾中药治疗,疗程为3个月。观察和检测治疗前后临床疗效、临床症状积分、T淋巴细胞亚群、药物安全性指标。结果:对照组有效率及临床受益率为31.1%和71.1%,治疗组分别为54.2%和85.4%,治疗组优于对照组(P<0.05);与对照组比较,治疗组对T淋巴细胞亚群具有明显的调节作用,在改善临床症状评分方面效果优于对照组(P<0.05);中药运用未见明显不良反应。结论:温脾补肾法具有提高中晚期恶性肿瘤患者临床疗效、改善患者的生存质量、不良反应少的综合效果,其作用机制可能是通过对免疫功能的调节而实现。
This study was aimed to evaluate impacts on immune regulation with spleen-strengthening and kidney-tonifying method among advanced malignant tumor patients. The enrolled advanced malignant tumor patients were randomly divided into the control group and the treatment group. The control group was treated with conventional treatment plan. The treatment group was treated with spleen-strengthening and kidney-tonifying Chinese herbs on the basis of conventional treatment plan for three months. Clinical effect, integral of clinical symptom （ICS）, T-lym-phocyte subsets, and drug safety index were observed and detected before and after treatment. The results showed that the effective rate and response rate in the control group were 31.1% and 71.1%, respectively. And the effective rate and response rate in the treatment group were 54.2% and 85.4%, respectively. The treatment group was better than the control group （P〈 0.05）. Compared to the control group, the treatment group had obvious regulation on T-lymphocyte subsets. The improvement on ICS in the treatment group was better than the control group （P 〈 0.05）. There was no obvious adverse reaction with the application of Chinese herbs. It was concluded that the spleen-strengthening and kidney-tonifying method can improve clinical effect, life of quality, and reduce adverse reaction a-mong advanced malignant tumor patients. Its mechanism may be through the regulation of immune function.
出处
《世界科学技术-中医药现代化》
北大核心
2014年第6期1322-1326,共5页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
茂名市科技局2013年医学类科技计划项目(2013165):艾可清Ⅱ号联合HAART疗法对AIDS患者免疫重建临床疗效的研究
负责人:李茂清
关键词
温脾补肾
中晚期恶性肿瘤
免疫调节
作用机制
Spleen-strengthening and kidney-tonifying method
advanced malignant tumor
immune regulation
action mechanism
