摘要
目的研究寒凉性中药对正常动物机体状态的影响。方法取雄性SD大鼠24只,分为寒性中药组、对照组。寒性中药组灌胃寒凉中药(黄连、黄芩、黄柏1:1:1),观察大鼠一般体征;放射免疫法检测血清三碘甲状腺原氨酸(T3)、甲状腺素(T4)、反三碘甲状腺原氨酸(rT3)、皮质酮/肾上腺酮(CORT)、环磷酸腺苷(cAMP)、环磷酸鸟苷(cGMP);紫外分光光度法测17-羟皮质类固醇(17-OHCS)、血糖(GLU)、甘油三脂(TG)、总胆固醇(TC)、总蛋白(TP)、白蛋白(ALB)、尿酸(UA)谷丙转氨酶(GPT)、谷草转氨酶(GOT)、尿素氮(BUN)、肌苷(CRE)、免疫球蛋白M(IgM)、免疫球蛋白uG(IgG)、补体C3、补体C4。结果与对照组比较,寒凉中药组大鼠出现活动减退现象,肛温明显降低;血清T3、CORT含量明显降低,17-ohcs含量有降低趋势;血浆cAMP含量、cAMP/cGMP值明显降低。物质代谢和肝肾功能的指标变化不明显。结论寒凉中药作用于正常机体,可使动物体重、甲状腺、肾上腺皮质功能低下,类似于临床虚寒状态,并体现寒凉类中药寒凉耗损机体阳气的药性特点。
Objective to study the effects of cold nature Chinese medicine on normal animal body status. Methods 24 male SD rats, divided into cold nature medicine group, the control group. The cold nature medicine group were perfused with cold nature medicine （ Coptis, Scutellaria, Phellodendron 1 ： 1 ： 1 ）, we observed the general signs ; radioi Y for three triiodothyronine （ T3 ）, thyroxine （ T4 ）, anti - three triiodothyronine （ rT3 ）, corticosterone / corticosterone （CORT）, cyclic phosphate adenosine（cAMP）, cyclic guanosine monophosphate （cGMP） ; 17 - hydroxy corticosteroids ultraviolet spectrophotometry （17 -OHCS）, blood glucose （GLU）, glycerin three fat （TG）, total cholesterol （TC）, total protein （TP）, albumin （ALB）, uric acid （UA） alanine aminotransferase （GPT）, aspartate aminotransferase （GOT）, blood urea nitrogen （BUN）, creatinine （CRE）, immunoglobulin M （IgM）, immunoglobulin uG （IgG）, complement C3, complement CA. Results compared with the control group, the cold medicine group rats showed activity decline, rectal temperature decreased significantly; the serum levels of T3, CORT content decreased, 17 - OHCS content decreased; the plasma levels of cAMP, cAMP/ cGMP decreased. Indicators of changes in metabolism and liver and kidney function is not obvious. Conclusion cold nature medicine effect on normal body, can make the animal weight, thyroid, adrenal cortical hypofunction, similar to the clinical deficiency status, and embodies the characteristics of traditional Chinese cold nature medicine make the body lose yang qi.
出处
《陕西中医学院学报》
2014年第4期72-74,113,共4页
Journal of Shaanxi College of Traditional Chinese Medicine
基金
国家自然科学基金项目(81303243)
国家中医药管理局重点学科建设项目
关键词
寒性药
机体状态
实验研究
cold nature medicine
health status
experimental study
