摘要
目的:探讨目前国内外常用的三种术后认知功能障碍(Postoperative Cognitive Dysfunction,POCD)诊断标准的合理性。方法:以100名中青年健康志愿者为研究对象,采用神经心理学测验测定认知功能三次,第一次测定(T0)作为基础值,第二次测定1(T1)和第三次测定(T2)分别与第一次测定间隔3d和30d。分别按照自身对比法、标准差法和Z计分法检测健康人群中T1和T2时认知功能变化程度超出正常范围的人数。以检测结果服从正态分布为判断标准。结果:完成全程测量者80人。按照三种POCD诊断标准诊断,在T1时,认知功能提高人数分别是认知功能降低人数的30倍、17倍和1倍,在T2时分别是32倍、26倍和1.5倍。结论:在采用神经心理学方法研究POCD时,用Z计分法诊断POCD比自身对比法和标准差法更能准确地反映认知功能的客观变化。
Objective： To investigate the rationality of three diagnosis criterions on postoperative cognitive dysfunction（POCD）used in clinical study of POCD. Methods： After Research Ethics Board approval and informed consent, 100 young and middle-age healthy volunteers were recruited. We then measured and analyzed their cognitive function change with a battery of six neuropsychological tests on three occasions： first time（T0, baseline） and 3 day（T1）, 30 day（T2） after the first time. The cases of cognitive improvement and cognitive dysfunction on T1 and T2with three ways, self comparison, standard deviation and Z score were detected to assess the rationality of those. The criterion of rationality is that the detecting results follow the normal distribution. Results： 80 objects had finished all the tests. The ratio of cognitive improvement and cognitive dysfunction according to the three ways were 30, 17, 1 at T1 and 32, 26, 1.5 at T2, respectively. Conclusion： Z score may be more accurate to reflect the objective change of cognitive function than self comparison and standard deviation when neuropsychological tests are administered in clinical study of POCD.
出处
《现代生物医学进展》
CAS
2014年第23期4550-4552,4557,共4页
Progress in Modern Biomedicine
基金
石河子大学医学院院级科研项目(YL2011S029)
关键词
认知障碍
神经心理学测验
诊断
标准
学习效应
Cognitive dysfunction
Neuropsychological tests
Diagnosis
Criterion
Learning effects
