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右美托咪啶对老年患者术后认知功能的干预作用研究及分析

Study on the Intervention Effect of Dexmedetomidine on Postoperative Cognitive Function in Elderly Patients
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摘要 目的研究和分析右美托咪啶对老年患者术后认知功能的干预作用。方法选取2014年7月—2015年7月在我院行腹腔镜手术的70例老年患者作为研究对象。按照入院时间,将其随机分为两组,每组各35例患者。观察组患者在手术中使用右美托咪啶进行泵注,而对照组患者在手术中则使用生理盐水进行泵注,将两组患者术前以及术后的MMSE评分、麻醉恢复情况进行对比。结果两组患者的麻醉时间对比,差异无统计学意义(P>0.05);观察组患者的拔管时间以及应答时间均短于对照组,差异具有统计学意义(P<0.05)。两组患者术前MMSE评分对比,差异无统计学意义(P>0.05);术后6 h、12 h以及24 h,观察组患者的MMSE评分高于对照组,差异具有统计学意义(P<0.05)。结论在老年手术患者中使用右美托咪啶,能够有效防止其出现认知功能障碍的情况。 Objective To investigate and analyze the intervention effect of dexmedetomidine on postoperative cognitive function in elderly patients. Methods 70 elderly patients undergoing laparoscopic surgery in our hospital from July 2014 to July 2015 were selected as the subjects. According to the admission time, they were randomly divided into two groups, 35 patients in each group. The patients in the observation group were treated with dexmedetomidine during the operation, patients in the control group were pumped with saline during the operation, the preoperative and postoperative MMSE scores and the recovery of anesthesia were compared between the two groups. Results There was no significant difference in the anesthetic time between the two groups (P 〉 0.05). The extubation time and response time of the Observation group were shorter than those of the control group, the difference was statistically significant (P 〈 0.05). There was no significant difference between the two groups in preoperative MMSE score (P 〉 0.05). After 6 h, 12 h and 24 h, the MMSE score of the observation group was higher than that of the control group, the difference was statistically significant (P 〈 0.05). Conclusion Dexmedetomidine can effectively prevent cognitive dysfunction in elderly surgical patients.
作者 杨坤渹 胡颖 李扬 李敬平 YANG Kunqing HU Ying LI Yang LI Jingping(Department of Anaesthesia, Mingda Hospital Affiliated to Hubei Institute for Nationalities, Enshi Hubei 445000, Chin)
出处 《中国继续医学教育》 2017年第21期80-81,共2页 China Continuing Medical Education
关键词 右美托咪啶 老年患者 术后认知功能 影响 dexmedetomidine elderly patients postoperative cognitivefunction impact
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