摘要
目的比较七氟醚与异氟醚吸入全身麻醉的苏醒情况以及二者对老年患者术后早期认知功能的影响。方法择期全身麻醉下行腹部手术老年患者60例,随机分为两组,全身麻醉诱导后I组(n=30)患者以异氟醚维持麻醉,II组(n=30)患者以七氟醚维持麻醉;监测麻醉期间心率、平均动脉压、输液量,记录患者手术后苏醒时间、拔管时间以及简易智力状态检查(MMSE)评分。结果两组患者年龄、体重、手术时间和麻醉时间差异无显著性(P>0.05);II组患者麻醉期间心率、输液量低于I组(P<0.05);II组患者术后苏醒时间、拔管时间以及术后第1dMMSE评分均优于I组(P<0.05);术后第3d两组患者MMSE评分差异无显著性(P>0.05)。结论七氟醚与异氟醚均可能影响老年患者全身麻醉术后早期认知功能,但七氟醚较异氟醚恢复更快。
Objective To compare the cognitive function after isoflurane versus sevoflurene anesthesia in aged patients. Methods Sixty aged patients received abdominal surgery under general anesthesia were randomly assigned to two groups. Following the induction, isoflurane （group Ⅰ） or sevoflurane （group Ⅱ） was respectively inhaled to maintain anesthesia. The parameters of MAP, HR and the volume of infusion were recorded. Awaking time and extubation after operation were recorded. The postoperative mini- mental state examination （MMSE） and adverse events correlated to the anesthesia and analgesia were collected. Results There were no significant differences between the two groups in age, sex, bodyweight, duration of anesthesia and surgery （P〉0.0.5）. The HR and the volume of infusion in group Ⅱ were lower than those in group Ⅰ （P〈0.05）. Awaking time and extubation after operation in group Ⅱ were shorter than that in group Ⅰ. The MMSE in group Ⅰ at the postoperative first day was better than that in group Ⅱ. No significant difference was found in MMSE between the two groups on the preoperative and postoperative day 3. Conclusions Both isoflurene and sevoflurane may contribute to the postoperative cognitive dysfunction in aged patients, but the recovery of influence caused by sevoflurane is faster than that caused by isoflurene.
出处
《实用预防医学》
CAS
2006年第3期501-502,共2页
Practical Preventive Medicine
基金
湖南省卫生厅科研课题资助项目(B2005065)
中南大学湘雅三医院博士化基金资助项目(0503)
关键词
七氟醚
异氟醚
全身麻醉
认知障碍
Isoflurane
Sevoflurane
General anesthesia
Cognitive dysfunction
