摘要
目的探讨影响强直性脊柱炎(AS)活动状态的因素,找出独立关键影响因素以指导临床,服务于患者。方法应用单因素分析AS活动状态的可能影响因素,进而以BASDAI(Bath)强直性脊柱炎活动指数为因变量、可能有影响的单因素作为自变量,纳入Logistic Cox回归方程。结果疾病活动期血沉(ESR)、C反应蛋白(CRP)、免疫球蛋白IgG和IgA、血清TNF-α均明显高于稳定期和健康对照组(P<0.05),而TNFβ在各组间差异无统计学意义(P>0.05)。Logistic Cox回归分析进入方程的变量为ESR、血清TNF-α。结论 ESR、血清TNF-α、临床指标BASDAI可能是影响AS活动状态的独立影响因素。
【Objective】 To investigate the factors that affect ankylosing spondylitis(AS) activation and find out the key factors to identify clinical, service patients. 【Methods】 Factors that may affect the application of single factor analysis AS active, use single factor analysis of factors that may affect the AS activity status, further as BASDAI(Bath Ankylosing Spondylitis disease. Activity Index) to the dependent variable, perhaps influential single factor as independent variables, add in Logistic Cox regression equation. 【Results】 Disease activity of erythrocyte sedimentation rate(ESR), C-reactive protein(CRP), Immunoglobulin IgG, IgA,Serum TNF-α all were significantly higher than stable and healthy control group(P〈0.05), while TNF- β among the groups was not statistically difference(P〉 0.05). Logistic Cox regression analysis, the variables into the equation ESR, serum TNF- α. 【Conclusion】 ESR, serum TNF- α, clinical indicators of BASDAI may be the active independent factors that affect AS activity.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2014年第17期68-70,共3页
China Journal of Modern Medicine
基金
河南省教育厅资助项目(No:2008A320008)