摘要
目的按不同临床因素分组观察强直性脊柱炎(AS)患者骨钙素(BGP)、抗酒石酸酸性磷酸酶(TRACP)的变化。方法采用ELISA试剂盒检测60例AS患者和健康对照组BGP、TRACP的变化,然后比较该两项指标在不同性别、年龄、病程、疾病活动性AS患者中的差异。结果 (1)与健康对照组比较,AS患者组TRACP水平明显增高(P<0.01),而BGP水平明显降低(P<0.05)。(2)60例AS患者中按不同临床因素分组后比较骨代谢指标变化:①男性组的TRACP比女性组的TRACP明显增高(P<0.05),而两组BGP比较差异无统计学意义(P>0.05);②>30岁组BGP显著低于≤30岁组,而TRACP显著高于≤30岁组(P<0.01或P<0.05);③病程>5年组的TRACP比病程≤5年组的TRACP明显增高(P<0.01),而病程>5年组AS患者的BGP较病程≤5年组AS患者的BGP明显降低(P<0.01);④疾病活动组的TRACP比缓解组的TRACP明显增高(P<0.01),而疾病活动组的BGP较缓解组的BGP明显降低(P<0.01)。结论 AS患者骨代谢特点表现为血清BGP水平的降低,TRACP水平的升高,并在不同性别、年龄、病程中存在着明显的差异,同时受到疾病活动的影响。
Objective To observe the changes of serum Bone Gla Protein(BGP)and Tartrate-Resistant Acid Phosphatase(TRACP)according to different clinical factors in patients with Ankylosing Spondylitis(AS).Method Enzyme-linked immunosorbent assay(ELISA)was used to detect the level of serum BGP and TRACP,and the differ-ence in sex,age,course of disease,disease activity were compared in patients with AS.Results (1)Compared with health control group,the level of TRACP in the treatment group was increased,while the level of BGP was decreased (P <0.05 or P <0.01).(2)The changes of serum bone metabolism index according to clinical factors in sixty AS patients:① the level of TRACP in male group was higher than that in female group(P <0.05),while there was no statistical difference in the level of BGP between the two groups.②The level of BGP in the age >30year-old patients group was lower than that of younger patients group,while the level of TRACP was higher than that of the latter(P <0.01 or P <0.05).③ the level of TRACP in duration >5 years group was higher than that in duration ≤ 5 years group,while the level of BGP was on the contrary(P <0.01).④ the level of TRACP in patients with active period of AS was significantly higher compared with patients with non-active period of AS,while the level of BGP was on the contrary(P <0.01).Conclusion In patients with AS,the levels of BGP is significantly decreased,and the levels of TRACP is significantly increased,both of which have a close correlation with sex,age,course of disease,disease activity.
出处
《中国临床保健杂志》
CAS
2013年第6期587-590,共4页
Chinese Journal of Clinical Healthcare
基金
国家自然科学基金(81173211)
国家中医药重点学科中医痹病学建设项目-国中医药发[2009]30号
安徽省2011年科技计划项目(11010402170)
安徽省科技厅科研计划项目(09020304046)
安徽省卫生厅中医药科研项目(2009ZY05)
安徽中医学院科技创新团队项目(2010TD005)
中国中医科学院自主选题团队建设:中国病症古代文献整理研究
关键词
脊柱炎
强直性
骨钙素
酸性磷酸酶
因果律
Spondylitis,ankylosing
Osteocalcin
Acid phosphatase
Causality
