摘要
目的 研究VEGF在喉癌转移及复发中的作用。方法 通过对 40例喉癌及转移淋巴结的VEGF免疫荧光染色 ,研究喉复发癌及转移癌的VEGF表达特性 ,并通过图像分析系统 ,分析其表达量 ,研究VEGF与喉癌转移的关系。结果 喉癌血管内皮细胞有较强的VEGF表达 ,有转移的喉原发癌及复发癌中VEGF染色强于无转移的原发癌 ,统计学比较具显著性差异 (P <0 .0 5)。结论 VEGF为血管内皮细胞浆表达蛋白 ,肿瘤细胞具有VEGF蛋白分泌功能 ,VEGF的过度表达与喉癌的转移、复发有关。VEGF的过度表达 。
Objective To investigate the relationship of the vascular endothelial growth factor(VEGF) with the recurrence and metastasis of laryngeal cancer.Methods The overexpression of VEGF in laryngeal cancer was quantitatively observed with immunofluorescent histochemistry by image analysis systems.Results In normal laryngeal tissues,VEGF mainly expressed in vascular endothelial of the submucous layer.There was a higher expression in metastastic cancer.In recurrent cancer,there was a strong expression in cytoplasms of cancer cell.The statistical difference was significant(P<0.05).Conclusion Immunofluorescent histochemistry is a useful method to examine the expression of VEGF in laryngeal cancer.The overexpression of VEGF are correlated with recurrent and metastasis of laryngeal cancer.
出处
《中国肿瘤临床与康复》
2002年第4期61-62,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
