摘要
目的探讨喉癌中血管内皮生长因子C(Vascularendothelialgrowthfactor-C,VEGF-C)的表达与淋巴道转移的关系。方法免疫组化SP法,对54例喉癌组织行VEGF-C检测及癌周组织毛细淋巴管计数,应用全自动图像分析仪对染色结果进行定量测定,以平均灰度值表示VEGF-C的染色强度。结果喉癌组织内VEGF-C表达高于声带息肉(P<0.05);颈淋巴结转移组高于非转移组(P<0.01)。癌周组织毛细淋巴管密度高于对照组正常喉组织(P<0.01);颈淋巴结转移组高于非转移组(P<0.01)。喉癌组织内VEGF-C表达与癌周组织淋巴管密度呈正相关(r=0.603,P<0.01)。结论喉癌组织中VEGF-C的表达与癌周毛细淋巴管密度关系密切,VEGF-C高表达促进淋巴管增殖,促进淋巴道转移。
Objective： To investigate the relationship of the expression of VEGF-C and the metastasis of the lymphoid nodes in laryngeal cancer. Methods： Using immunohistochemistry method, the expression of VEGF-C in the tumor tissues and the density of lymphatic in adjacent tissue of laryngeal carcinoma were detected. Results：The expression of VEGF-C in laryngeal carcinoma was higher than in vocal cord polyp and in lymphoid node-positive was higher than in node-negative. Density of lymphatic capillary in adjacent tissue of laryngeal carcinoma was much higher than in normal laryngeal tissue and in lymphoid node-positive was higher than in node-negative. Conclusion：VEGF-C protein expression is close to lymphatic metastasis.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2007年第1期82-84,共3页
Chinese Journal of Immunology
关键词
喉癌
VEGF—C
淋巴管
免疫组化
VEGF-C
Laryngeal carcinoma
Metastasis
Immunohistochemistry
