摘要
目的探讨血清、尿游离轻链检测的临床应用。方法利用速率散射比浊法对临床确诊的45例结缔组织病(CTD)及43例多发性骨髓瘤(MM)患者血清和尿液中游离轻链进行测定。结果 CTD组血清与尿κ型轻链含量明显低于κ型MM组(P<0.05),CTD组血清与尿λ型轻链含量亦明显低于λ型MM组(P<0.05);CTD组血清与尿κ/λ比值低于κ型MM组(P<0.05),高于λ型MM组(P<0.05)。45例CTD组血清轻链检测无一例表现为κ/λ比值失衡,而43例MM组中有41例表现为比例失衡。结论对免疫球蛋白明显升高的CTD,为了解是否同时存在MM,血清与尿κ、λ及κ/λ比值测定有临床应用价值。
Objective To discuss the clinical application of serum and urine free light chain detection.Methods The levels of free light chain in serum and urine were measured in the cases of connective tissue disease(CTD)and multiple myeloma (MM)by nephelometry. Results The levels of light chainκin serum and urine of CTD patients were lower than those of type κMMpatients(P<0.05).The levels of light chain λin serum and urine of CTD patients were also lower than those of type λMM patients(P<0.05).The serum and urineκ/λratio of CTD patients was lower than that of type κMM patients (P<0.05 ),but higher than that of type λMM patients (P<0.05 ). There was no one ratio imbalance of the serumκ/λin CTD patients,while there were 41 in MM patients.Conclusion For CTD in which im-mune globulin is significantly high,light chain testing can help to understand whether MMexists.The serum and urineκ,λandκ/λratio have value in clinical application.
出处
《安徽医学》
2014年第6期737-739,共3页
Anhui Medical Journal
关键词
免疫球蛋白
游离轻链
结缔组织病
多发性骨髓瘤
Immune globulin
Free light chain
Connective tissue diseases
Multiple myeloma
