摘要
目的了解认知功能正常的老年人认知功能变化与不同载脂蛋白E(APOE)基因型及血管性风险因子的关系。方法对118例认知功能正常的老年人进行随访,观察简易智能状态检查(MMSE)评分的改变和痴呆发生率与APOE基因型以及血管性风险因子的关系。结果有APOE4基因型的老人与没有APOE4基因型的老人相比,每年的MMSE评分降低速度快、冠心病的患病率高、痴呆发病率高。结论APOE4基因型不仅是痴呆的独立风险因子,也与多种血管性风险因子的作用相关。
Objective To evaluate the correlation between cognitive changes and APOE genotype as well as vascular risk factors among the cognitively normal elderly. Methods Longitudinally followed up 118 cognitively normal elderly, compared their annual MMSE changes, incidence of dementias with APOE4 genotypes and vascular risk factors. Results Compared with those without APOE4 genotype, the elderly who have APOE4 genotype showed increased MMSE score decline, high prevalence of coronary heart disease, and high incidence of dementia. Conclusions APOE4 genotype is not only the independent risk factor for cognitive decline but also affecting vascular risk factors.
出处
《老年医学与保健》
CAS
2002年第2期103-104,107,共3页
Geriatrics & Health Care
