摘要
目的探讨精氨酸增强的胃肠外营养对结直肠癌患者术后的免疫功能的影响。方法随机选择在南方医院普外科住院治疗的40例结直肠癌患者,术后分别接受常规肠外营养支持或精氨酸增强的肠外营养支持(20 g/d)1周,检测及分析术前、术后不同时期的免疫功能(包括CD3+、CD4+、CD8+、CD4+/CD8+、IL-2R、NK、C3、C4、CH50、IgG、IgA、IgM等指标)。结果结直肠患者入院时均有明显的免疫抑制,精氨酸增强的肠外营养支持组患者的免疫功能(CD4+、CD4+/CD8+NK、IL-2R)在术后第4天、第7天与对照组相比有明显改善(P<0.05)。结论精氨酸能改善大肠癌患者术后的免疫功能,增进肠外营养的效果。
Objective To study the effects of parenteral nutrition (PN) supplemented with L-arginine on the immune function of patients with colorectal cancer after operation. Methods Forty randomly chosen patients with colorectal cancer were en-rolled in this study, who received either standard PN or PN supplemented with 20 g/d L-arginine for 7 d after surgical removal of the tumors. Tests of the immune function (CD3 + , CD4 + , CD8 + , CD4 + /CD8 + ,interleukin-2R, natural killer cells, C3, C4, CH50, IgA, IgM, IgG) were performed preoperatively and at different time periods postoperatively. Results Data analysis with ANOVA demonstrated immune suppression in the patients before operation, and the condition was improved (as evidenced by increased CD4 + ,CD4 + /CD8 + , natural killer cells and interleukin-2R levels) in L-arginine group as compared with the results in the control group at days 4 and 7 (P<0.05). Conclusion Arginine can improve the immune function in patients with colorectal cancer after operation and enhance PN effect.
出处
《第一军医大学学报》
CSCD
北大核心
2002年第6期545-549,共5页
Journal of First Military Medical University
