摘要
观察了环维黄杨星D(CVB-D)对急性分离心肌细胞内游离Ca^(2+)浓度的影响。应用特异性荧光指示剂Fluo-3′AM负载细胞,用激光共聚焦显微镜检测胞内游离钙的变化。结果表明,CVB-D在10^(-3),10^(-(?))mol′L时均可升高心肌细胞内游离钙离子浓度,此作用随剂量增加而增加。因此CVB-D具有升高心肌细胞内游离子钙离子浓度的作用。
The aim is to observe the effect of cyclovirbuxine-D (.CVB-D) on intracellular free Ca2+ concentration in acute isolated cardiomyocytes. Intracellular calcium concentration was measured using Ca:' indicator Fluo- 3 ' AM and laser scanning confocal microscopy. CVB-D was found to increase intracellular free Ca2+ concentration in a dose-dependent manner. So CVB-D could increase cardiomyocytes intracellular free Ca2+ concentration.
出处
《江苏药学与临床研究》
2001年第1期10-12,共3页
Jiangsu Pharmacertical and Clinical Research
