摘要
环维黄杨星Ｄ（ＣＶＢ－Ｄ）１～１０μｍｏｌ／Ｌ和哇巴因合用后，离体豚鼠心肌收缩力增强，收缩和舒张时间缩短，平均收缩速度和舒张速度加快，最大反应增加。 ＣＶＢ－Ｄ１～１０ｕｍｏｌ／Ｌ增强异丙肾上腺素、去氧肾上腺素、组胺和 ＣａＣｌ２的正性肌力作用，使其量效曲线左移，最大反应增加。 ＣＶＢ－Ｄ能对抗维拉帕米和 Ａｃｈ５ｕｍｏｌ／Ｌ所致的负性肌力作用。结果表明，ＣＶＢ－Ｄ正性肌力作用的机理可能与 ａ、β和 Ｈ２－受体、电压依赖钙通道激动剂及哇巴因不同，而与促进心肌细胞外Ｃａ２＋内流和抑制内Ｋ＋外流有关。
In isolated guinea pig left atreia, the combinced use of cyclovirobuxine(D(CVB-D) and ouabain caused a more significant increase in contractile force, a greater shortening in con- traction time, defined as the time from onset to peak force, and relaxation time and a more remarkable augmentation in both contraction rate and relaxation rate. CVB-D1 ~ 10umol/L enhanced the positive inotropic effects of isoprenaline, phenylephrine, histamine and calcium, shifting their dose-response curves to the left and increasing their maximal responses. The negative inotropic action of verapamil or acetylcholine 5umol/L was inhibited and even abolished after the medication of CVB-D 10-100umol/L. It is suggested that the mechanism for the positive in otropic effect of CVB-D might be different from that of ouabain, a-, B- and H2-receptor agonists as well as voltage-dependent calcium channel agonist, associating with an increase in transsarcolemmal influx of calcium and a decrease in transsarcolemmal outflow of potassium.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1994年第1期20-23,共4页
Chinese Pharmaceutical Journal
关键词
环维黄杨星D
哇巴因
心肌收缩
cyclovirobuxine-D, ouabain, verapamil, acetylcholine, isoprenaline, myocardial contraction
