摘要
目的 :研究急性脑梗死患者血清转化生长因子 β1(TGF - β1)的变化 ,以探讨其临床意义。方法 :采用双抗体夹心酶联免疫吸附法检测 33例急性脑梗死患者发病后 1天、3天、7天的血清TGF - β1水平 ,并与 31例健康人作对照。结果 :脑梗死患者血清TGF - β1含量在第 1、3天均明显低于对照组 (P <0 0 1) ,而第 7天两组比较无显著差异 (P >0 0 5 ) ,血清TGF - β1降低的程度在急性期与梗死体积大小和神经功能缺损程度无密切关系 (P >0 0 5 ) ,而在恢复期与神经功能缺损程度呈负相关 (r= - 0 5 74 ,P <0 0 5 )。结论 :脑梗死急性期测定血清TGF -
Objective:To investigate the change of transforming growth factor-beta 1(TGF-β1) in serum of patients with acute cerebral infarction,so as to explore the clinical significance.Methods:The serum levels of TGF-β1 were measured by ELISA in 33 patients with acute cerebral infarction at 1?3 and 7 days after stroke onset and in 31 cases healthy control.Results:The serum TGF-β1 levels in the patient group were significantly lower at day1?day3 than that in control group(P<0 01),and not significantly different at day 7(P>0 05).The decreased serum TGF-β1 level had not correlation with the infarct volume and the degree of neurological deficit in acute stage(P>0 05),and had negative correlation with the degree of neurological deficit in recovery stage(r=-0 574,P<0 05).Conclusions:The TGF-β1 in serum may be a effective parameter to make the diagnosis and judge the prognosis of acute cerebral infarction.
出处
《广西医学》
CAS
2002年第6期776-777,共2页
Guangxi Medical Journal
