摘要
目的探讨地尔硫[艹卓]治疗左室射血分数保留型心力衰竭的临床疗效。方法将左室射血分数保留型心力衰竭患者87例分为对照组和治疗组。对照组42例,给予基础抗心力衰竭治疗;治疗组47例,在基础治疗上加用地尔硫。治疗3个月后观察心功能分级(NYHA)、6min步行距离、舒张早期二尖瓣血流速度与舒张早期二尖瓣环运动速度的比值(E/E′)、脑钠肽(BNP)水平。结果治疗组总有效率高于对照组(62.22%vs.47.62%,P<0.05),治疗组治疗后6min步行距离明显延长(m:520.63±62.41vs.223.64±23.47),E/E′(8.28±4.92vs.10.28±5.21)及BNP水平(pg/mL:223.64±23.47vs.170.36±21.39)明显下降,均优于对照组(P<0.05)。结论地尔硫能够改善左室射血分数保留型心力衰竭患者的心功能和临床症状。
Objective To investigate the effectiveness of diltiazem in heart failure with preserved ejection fraction (HF -PEF)patients.Methods The study involved 87 subjects diagnosed with HF-PEF.They were randomly divided into two group:42 subjects assigned into control group, received traditional anti -heart failure optimal medical therapy;47 subjects assigned into treatment group,not only received traditional optimal medical therapy but also diltiazem therapy.The New York Heart Association (NYHA)functional class and six-minute walking test (6MWT)and B -type natriuretic peptide (BNP)were recorded,ratio of mitml velocity to early diastolic velocity of the mitral annulus were detected by echocardiogram before and after treatment.The treatment lasted three months. Results The total effective rate (62.22%vs.47.62%)in treatment group was higher than it in control group,while 6MWT(m:520.63±62.41 vs.223.64±23.47)and E/E'(8.28 ±4.92 vs.10.28 ± 5.21)and BNP (pg/mL:223.64 ±23:47 vs.170.36 ±21.39)in treatment group after treatment improved significantly than those in control group.There was statistically significant difference (P < 0.05).Conclusion Diltiazem could improve the symptoms and cardiac diastolic function in HF -PEF.
作者
李斌
康爱玲
沈洁
陈德昌
Li Bin;Kang Ai-ling;Shen Jie;Chen De-chang(Shanghai Jiading Anting Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201805, China)
出处
《中国急救医学》
CAS
CSCD
北大核心
2019年第2期161-164,共4页
Chinese Journal of Critical Care Medicine
基金
上海市卫生和计划生育委员会科研课题(20134375).
