摘要
目的探讨住院2型糖尿病(T2DM)患者不同性别骨量减少(包括骨质疏松与低骨量)相关影响因素及其与颈动脉粥样硬化斑块之间的关系。方法回顾性分析720例T2DM患者的临床资料,将入选对象分为男性组和女性组,每组再分为骨量正常组和骨量减少组,颈动脉有斑块组和颈动脉无斑块组。结果在男性骨量减少组(77例)中,存在粥样斑块68例(88.31%),与骨量正常组(164例)比较,骨量减少组粥样斑块的发生率明显升高(P<0.05);斑块形成组骨密度(BMD)明显减低(P<0.05)。在女性骨量减少组(255例)中,存在粥样斑块191例(74.90%),与骨量正常组(224例)比较,骨量减少组粥样斑块的发生率明显升高(P<0.05);斑块形成组骨密度明显减低(P<0.05)。二元Logistic回归分析显示,男性骨量减少的影响因素有年龄(OR=1.059,P=0.002),体质指数(BMI)(OR=0.853,P=0.004),空腹血糖(FBG)(OR=1.138,P=0.044),有无颈动脉斑块(OR=2.514,P=0.035)。女性骨量减少的影响因素有年龄(OR=1.117,P=0.000),绝经年龄(OR=0.946,P=0.031),BMI(OR=0.910,P=0.003)。结论 T2DM患者颈动脉粥样硬化斑块与骨量减少密切相关。女性患者由于增龄等共同危险因素的存在,二者常相伴发生,然而在男性患者中,颈动脉粥样硬化斑块的形成是骨质疏松的危险因素,因此,颈动脉硬化的发展常伴有骨量变化,易发生骨质疏松。
Aim To investigate the correlation between carotid atherosclerotic plaque and bone mineral density(BMD) in patients with type 2 diabetes mellitus(T2DM).Methods Analysing the clinical data of 720 patients with T2DM,the selected subjects were divided into male group and female group,and each group was further divided into normal bone mass group and osteopenia group,carotid artery plaque group and without carotid artery plaque group.Results In the male osteopenia group(77 cases),there were 68 cases of atheromatous plaque(88.31%).Compared with the normal bone mass group(164 cases),the incidence of atherosclerotic plaque in the osteopenia group was significantly increased(P<0.05),and the bone mineral density(BMD) in the plaque formation group was significantly decreased(P<0.05).In the female osteopenia group(255 cases),191(74.90%) had atherosclerotic plaques.Compared with normal bone mass group(224 cases),the incidence of atherosclerotic plaques in osteopenia group was significantly increased(P<0.05),and BMD in plaque formation group was significantly decreased(P<0.05).Logistic regression analysis showed that the influence factors of male bone mass reduction included age(OR=1.059,P=0.002),BMI(OR=0.853,P=0.004),FBG(OR=1.138,P=0.044),presence of carotid artery plaque(OR=2.514,P=0.035);the influencing factors of female bone mass reduction included age(OR=1.117,P=0.000),menopause age(OR=0.946,P=0.031),BMI(OR=0.910,P=0.003).Conclusions Carotid atherosclerotic plaque is closely related to bone loss in T2DM patients,which often occurs together in women as a result of the existence of common risk factors.However,in male patients,the formation of carotid atherosclerotic plaques is a risk factor for osteoporosis.Therefore,the development of carotid atherosclerosis is often accompanied by changes in bone mass,which is prone to osteoporosis.
作者
于婷婷
黄娜娜
苏娇
孙英
周瑾
王秋灵
唐与晓
陈述林
YU Tingting;HUANG Nana;SU Jiao;SUN Ying;ZHOU Jin;WANG Qiuling;TANG Yuxiao;CHEN Shulin(Qingdao University,Qingdao,Shandong 266071;Department of Endocrinology,Linyi Central Hospital,Linyi,Shandong 276400;Department of Endocrinology,Affiliated Yantai Yuhuangding Hospital of Qingdao University,Yantai, Shandong 264000,China)
出处
《中国动脉硬化杂志》
CAS
2019年第1期45-50,共6页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金(81700695)
山东省自然科学基金(ZR2011HQ043)
关键词
颈动脉粥样硬化斑块
2型糖尿病
骨质疏松
骨密度
carotid atherosclerotic plaque
type 2 diabetes mellitus
osteoporosis
bone mineral density
