摘要
目的探讨糖尿病合并颈动脉斑块患者血清基质金属蛋白酶9(MMP9)及C反应蛋白(CRP)水平的表达情况,以及血清MMP9、CRP水平在不同颈动脉斑块形成中表达的差异。方法收集2019年1月至2019年12月内蒙古自治区人民医院收治的180例2型糖尿病患者的临床资料,根据颈动脉超声检查结果,将患者按照是否形成颈动脉斑块分为斑块组(n=81)和无斑块组(n=99),选取同期的健康体检者作为对照组(n=90)。检测所有患者入院时、血糖控制理想后,对照组相同时间点的血清MMP9及CRP水平;对斑块组患者行颈部多普勒血管超声检查。按照颈动脉斑块稳定性将患者分为稳定斑块和不稳定斑块,比较血清MMP9、CRP水平在不同颈动脉斑块形成中表达的差异。结果各时间段斑块组患者的血清MMP9、CRP水平均明显高于无斑块组和对照组患者,差异均有统计学意义(P<0.05)。各时间段不稳定斑块患者的血清MMP9、CRP水平均明显高于稳定斑块患者,差异有统计学意义(P<0.05)。多因素分析结果显示,血糖控制不理想、MMP9水平高、CRP水平高均是2型糖尿病合并颈动脉斑块患者颈动脉斑块稳定性的独立危险因素(P<0.05)。结论糖尿病合并颈动脉斑块患者的血清MMP9、CRP水平均较高,其中,颈动脉不稳定斑块患者的血清MMP9、CRP水平更高,且两者与颈动脉斑块的稳定性密切相关,可作为临床诊断糖尿病合并颈动脉斑块形成及斑块稳定性的重要血清标志物。
Objective To investigate the expression of serum matrix metalloproteinase 9(MMP9)and C-reactive protein(CRP)level in patients with diabetes mellitus combined with carotid plaque and the differences of serum MMP9 and CRP expression in the formation of different carotid plaques.Method The clinical data of 180 patients with type 2 diabetes mellitus in Inner Mongolia Autonomous Region People's Hospital from January 2019 to December 2019 were selected.According to the presence or absence of carotid plaque.They were divided into the combined with plaque group(n=81)and the non-plaque group(n=99).At the same time,90 healthy people during the same period were selected as the control group at the same time.Serum MMP9 and CRP levels of all patients were measured and recorded at when on admission and after glucose control.Neck Doppler ultrasonography was performed on the combined with plaque group,and the patients were divided into stable plaque group and unstable plaque group according to the stability of carotid plaque.The differences of serum MMP9 and CRP levels in the formation of different carotid plaques were compared and analyzed.Result The levels of serum MMP9 and CRP in plaque group were significantly higher than those in non-plaque group and control group,The levels of serum MMP9 and CRP in unstable plaque group were significantly higher than those in stable plaque group(P<0.05).Multivariate analysis showed that poor blood glucose control,high MMP9 level and high CRP level were independent risk factors for carotid atherosclerotic plaques in type 2 diabetic patients with carotid plaques(P<0.05).Conclusion Serum MMP9 and CRP levels were high in patients with diabetes mellitus complicated with carotid plaque,and higher in patients with unstable carotid plaque than those of patients with stable carotid plaque,and both were closely related to the stability of carotid plaque.So they can be used as important serum biomarkers for clinical diagnosis of diabetes mellitus complicated with carotid plaque formation and stabilit
作者
娜日苏
王秀艳
梅艳
邬晓春
丁海涛
刘贞庆
王淑芳
Narisu;Wang Xiuyan;Mei Yan;Wu Xiaochun;Ding Haitao;Liu Zhenqing;Wang Shufang(Health Management Center,Inner Mongolia Autonomous Region People's Hospital,Hohhot 010017,Inner Mongolia,China;Department of Clinical Laboratory,Inner Mongolia Autonomous Region People's Hospital,Hohhot 010017,Inner Mongolia,China)
出处
《血管与腔内血管外科杂志》
2021年第10期1169-1173,共5页
Journal of Vascular and Endovascular Surgery
基金
内蒙古自治区人民医院院内基金项目(201802)。
