摘要
肠易激综合征(IBS)是一种慢性胃肠功能紊乱性疾病,其临床表现主要以抑郁或焦虑症状和肠道症状为主,虽有明确的诊断标准,但发病机制目前尚无定论。现代研究发现IBS的发病与5-羟色胺(5-HT)的分泌异常有关,5-HT是体内重要的神经递质,5-HT信号系统包括5-HT的合成、释放、与受体结合、重吸收等多个过程。文章就以5-HT信号系统为切入点,对5-HT的前体合成物质--色氨酸羟化酶(TPH)和重吸收物质--5-羟色胺转运体(SERT)与IBS的关系作一综述。
Irritable bowel syndrome(IBS)is a kind of chronic disease with gastrointestinal dysfunction,and its clinical manifestations are mainly about depression,anxiety and gastrointestinal symptoms. However,there has no final conclusion about its pathogenesis though the diagnostic criteria is definite. The modern research has found that the incidence of irritable bowel syndrome was related to abnormal secretion of 5-HT. 5-HT is an important neurotransmitter in body,and the signal system of 5-HT includes many process like its synthesis,release,combining with receptor,reabsorption and so on. This article takes the signal system of 5-HT as the breakthrough point to explain the association among IBS and the synthetic substance of 5-HT(TPH)and its resorption(SERT).
作者
孙羽中
潘伟娟
窦志芳
SUN Yuzhong;PAN Weijuan;DOU Zhifang(Shanxi University of Chinese Medicine,Taiyuan 030024,Shanxi,China)
出处
《辽宁中医药大学学报》
CAS
2019年第1期83-86,共4页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家自然科学基金面上项目(81373509)
