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血清脑肠肽因子Obestatin、5-HT水平与老年溃疡性结肠炎患者情感障碍的相关性分析 被引量:2

Correlation analysis of serum brain gut peptide factor Obestatin and 5-HT levels with affective disorder in elderly patients with ulcerative colitis
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摘要 目的探讨血清脑肠肽因子肥胖抑制素(Obestatin)、5-羟色胺(5-hydroxytryptamine,5-HT)水平与老年溃疡性结肠炎(ulcerative colitis,UC)患者情感障碍的相关性分析。方法选取2019年4月至2021年1月于我院就诊的UC患者100例为研究对象,根据入院SAS和SDS评分分为有情感障碍组和无情感障碍组,每组各50例,收集两组患者5-HT、IL-6、IL-8、IL-2、Obestatin、TNF-α、丙二醛(malondialdehyde,MDA)、超氧化物歧化酶(superoxide dismutase,SOD)水平等临床资料,并进行统计学分析。结果有情感障碍组患者SAS、SDS评分明显高于无情感障碍组患者,差异有统计学意义(P<0.05)。有情感障碍组患者血清IL-6、IL-8和TNF-α表达水平高于无情感障碍组患者,IL-2低于无情感障碍组患者,差异有统计学意义(P<0.05)。有情感障碍组患者5-HT、Obestatin、SOD高于无情感障碍组患者,MDA低于无情感障碍组患者,差异有统计学意义(P<0.05)。Spearman相关性分析结果显示,5-HT与SAS(r=0.595,P=0.000)、SDS(r=0.364,P=0.000)有相关性,Obestatin与SAS(r=0.413,P=0.000)、SDS(r=0.317,P=0.000)有相关性,MDA、SOD与SAS、SDS无相关性。Logistic回归分析结果显示,5-HT(OR=2.034,P=0.006)、Obestatin(OR=1.786,P=0.008)是UC患者发生情感障碍的独立危险因素。5-HT诊断UC患者发生情感障碍的灵敏性为0.720,特异性为0.560,准确性为0.640;Obestatin诊断UC患者发生情感障碍的灵敏性为0.740,特异性为0.540,准确性为0.640;两者联合诊断UC患者发生情感障碍的灵敏性为0.820,特异性为0.520,准确性为0.670。结论5-HT、Obestatin是UC患者发生情感障碍的独立危险因素,且5-HT、Obestatin联合诊断UC患者发生情感障碍的诊断价值较高,临床价值较大。 Objective To investigate the correlation of serum brain gut peptide factors Obestatin,5-HT and affective disorder in elderly patients with ulcerative colitis(UC).Methods 100 patients with UC in our hospital from Apr.2019 to Jan.2021 were selected and divided into affective disorder group and non-affective disorder group according to admission SAS and SDS scores,with 50 cases in each group.The levels of 5-HT,IL-6,IL-8,IL-2,Obestatin,TNF-α,malondialdehyde(MDA),superoxide dismutase(SOD)were statistically analyzed.Results The SAS and SDS scores of patients with affective disorder were significantly higher than those of patients without affective disorder(P<0.05).The serum levels of IL-6,IL-8 and TNF-αin patients with affective disorder were higher than those in patients without affective disorder,and IL-2 was lower than those in patients without affective disorder(P<0.05).The levels of 5-HT,Obestatin and SOD in patients with affective disorder were higher than those in patients without affective disorder,and MDA was lower than those in patients without affective disorder(P<0.05).Spearman correlation analysis showed that 5-HT had correlation with SAS(r=0.595,P=0.000),SDS(r=0.364,P=0.000),Obestatin had correlation with SAS(r=0.413,P=0.000),SDS(r=0.317,P=0.000),MDA and SOD had no correlation with SAS and SDS.Logistic regression analysis showed that 5-HT(OR=2.034,P=0.006)and Obestatin(OR=1.786,P=0.008)were independent risk factors for affective disorder in patients with UC.The sensitivity,specificity and accuracy of 5-HT in the diagnosis of affective disorder in patients with UC were 0.720,0.560 and 0.640,respectively.The sensitivity,specificity and accuracy of Obestatin in the diagnosis of affective disorder in patients with UC were 0.740,0.540 and 0.640.The sensitivity,specificity,and accuracy of the combined in the diagnosis of affective disorder in patients with UC were 0.820,0.520 and 0.670,respectively.Conclusion 5-HT and Obestatin are independent risk factors for patient with affective disorder of UC,and the com
作者 张霞 杜文泽 赵汉清 张硕 ZHANG Xia;DU Wenze;ZHAO Hanqing;ZHANG Shuo(Department of Gastroenterology,the Second Affiliated Hospital of Hebei North University,Zhangjiakou 075100,China;Department of Ultrasound,the Second Affiliated Hospital of Hebei North University,Zhangjiakou 075100,China;Department of Traditional Chinese Medicine,the Second Affiliated Hospital of Hebei North University,Zhangjiakou 075100,China;Operation Room,the Second Affiliated Hospital of Hebei North University,Zhangjiakou 075100,China)
出处 《胃肠病学和肝病学杂志》 CAS 2022年第4期397-401,共5页 Chinese Journal of Gastroenterology and Hepatology
基金 河北省卫生健康委员会立项医学科学研究课题计划项目(20210847)。
关键词 溃疡性结肠炎 5-HT OBESTATIN 情感障碍 Ulcerative colitis 5-HT Obestatin Affective disorder
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