摘要
目的探讨老年恶性肿瘤患者合并发生弥散性血管内凝血(DIC)的危险因素及对预后的影响。方法选取2011年1月至2017年12月间辽宁省金秋医院收治的47例合并DIC的老年恶性肿瘤患者为DIC组,另选取同期接受治疗未发生DIC的42例老年恶性肿瘤患者为对照组。比较两组患者的临床资料及预后情况,分析老年恶性肿瘤患者发生DIC的危险因素。结果 DIC组患者的临床分期、感染人数、低蛋白血症、远处转移、AFP、CA125、CA153及CEA水平与对照组比较,差异均有统计学意义(均P <0. 05)。临床分期≥Ⅲ期、存在低蛋白血症及感染是导致老年恶性肿瘤患者并发DIC的独立危险因素,差异均有统计学意义(均P <0. 05)。对照组患者死亡3例(7. 1%),低于DIC组的40例(85. 1%),差异有统计学意义(P <0. 05)。结论临床需密切监控老年恶性肿瘤患者低蛋白血症及感染情况,及早干预,以降低DIC的发生率,改善预后。
Objective To investigate the risk factors for disseminated intravascular coagulation (DIC)in elderly patients with malignant tumors and the effect of DIC on prognosis.Methods From January 2011 to December 2017,47 elderly patients with malignant tumors who admitted to Jinqiu Hospital were selected as DIC group.Another 42 elderly patients with malignant tumors who were not found to have DIC during the treatment at the same time were selected as control group.The clinical data and prognosis were compared between the two groups,The risk factors for DIC in elderly patients with malignant tumors were analyzed.Results There was significant difference in clinical staging,number of infections,hypoproteinemia,distant metastasis,AFP,carbohydrate antigen 125(CA125),CA153,Carcinoembryonic antigen (CEA)levels between the two groups (all P <0.05).More than stage Ⅲ,hypoproteinemia and infection were independent risk factors for DIC in elderly patients with malignant tumors (all P <0.05).Forty patients died in the DIC group (85.1%)which was significantly lower than 3(7.1%)of the control group (P <0.01).Conclusion Clinical monitoring of hypoproteinemia and infection in elderly patients with malignant tumors is badly needed.Early intervention should be given to reduce the incidence of DIC and im- prove the prognosis.
作者
陈慧敏
赵冬
王明珠
CHEN Hui-min;ZHAO Dong;WANG Ming-zhu(Department of Geriatrics,Jinqiu Hospital,Shenyang 110016,China)
出处
《中国肿瘤临床与康复》
2018年第12期1499-1501,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
恶性肿瘤
老年患者
危险影响因素
血管内凝血
弥散性
预后
Malignant neoplasms
Elderly patients
Risk factors
Intravascular coagulation
Diffusion
Prognosis
