摘要
循环肿瘤DNA作为一种可以检测和量化肿瘤突变的观察指标在肿瘤的临床诊疗中的作用越来越突出。在卵巢癌的组织学分型中,上皮性卵巢癌占绝大多数。随着肿瘤的演进,肿瘤细胞内的DNA片段可进入血液循环,形成循环肿瘤DNA,其在上皮性卵巢癌的早期诊断、手术及辅助治疗的疗效判定、肿瘤负荷的评价、随访期的动态监测及预后分析等方面,均有一定的临床应用价值。
In the development of cancer, the DNA fragments of tumor cells enter into the blood circulation to form circulating tumor DNA (ctDNA), which is an indicator for detecting and quantifying tumor mutations. Epithelial ovarian cancer accounts for most of the histological types in ovarian cancer. This article reviews the clinical application of ctDNA in epithelial ovarian cancer, including the early diagnosis, therapeutic effect evaluation after operation and adjuvant therapy, tumor load assessment, dynamic monitoring during the follow-up and the prognosis of patients.
作者
王东营
吴飞
张炜旸
许天敏
Wang Dongying;Wu Fei;Zhang Weiyang;Xu Tianmin(Department of Obstetrics and Gynecology,The Second Hospital of Jilin University,Changchun 130041,China)
出处
《中华全科医师杂志》
2018年第12期1033-1037,共5页
Chinese Journal of General Practitioners
基金
吉林省科技发展计划(20150204007YY)
吉林省省级经济结构战略调整引导资金专项(2014G073,2016C046-2)。
关键词
DNA肿瘤
卵巢肿瘤
上皮
肿瘤细胞
循环
细胞游离DNA
肿瘤标记
生物学
DNA,Neoplasm
Ovarian neoplasms,epithelium
Neoplastic cells,circulating
Cell-free DNA
Tumor biomarkers,biologieal
