摘要
目的探讨Toll样受体4(Toll-like receptor 4,TLR4) 896A>G基因多态性与结直肠癌(colorectal carcinoma,CRC)易感性的关系。方法计算机检索有关TLR4基因多态性与CRC易感性关系的文献,通过阅读摘要及全文筛选出符合条件的文献,应用Rev Man 5.2及Stata 11.0软件对各项研究进行异质性检验,计算比值比(OR值),并进行敏感性分析和发表偏倚评估。结果共有12篇文献纳入本研究,包括2 709例CRC患者和3 717例对照者。Meta分析结果表明,TLR4 896A>G基因多态性与CRC发病风险无相关性[等位基因模型G/A:I^2=18%,P=0.27;显性模型AG+GG/AA:I^2=12%,P=0.33;隐性模型GG/AA+AG:I^2=0,P=0.75;共显性模型AG/AA:I^2=4%,P=0.40; GG/AA:I^2=0,P=0.74]。同时,亚组分析结果表明,在亚洲人群及白种人中TLR4896A>G基因多态性与CRC易感性均无显著相关性。结论 TLR4 896A>G基因多态性与CRC易感性无明显相关性,受纳入文献数量及质量的限制,上述结论尚需开展更多研究予以验证。
Objective To investigate the effects of Toll-like receptor 4(TLR4)896A >G polymorphisms on colorectal carcinoma (CRC)risk.Methods Literatures under the same CRC between polymorphism of TLR4896A >G and susceptibility of CRC were collected by computer-based retrieval.The RevMan 5.2 and Stata 11.0 software were used for statistical analysis,sensitivity and publication bias of the literatures.Results A total of 12literatures with domestic and foreign 2709 cases and 3717 controls were included.The results of Meta-analysis showed that the correlation between polymorphism of TLR4896A >G gene and susceptibility of CRC had no statistical significance [allele model G/ A:I^2=18%,P =0.27;dominant model AG +GG/AA:I^2=12%,P =0.33;dominant model GG/AA +AG:I^2=0,P = 0.75;co-dominant model AG/AA :I^2=4%,P =0.40,GG/AA :I^2=0,P =0.74].In the meantime,no significant association was observed in subgroup analysis based on ethnicity.Conclusion There is no relationship between polymorphism of TLR4896A >G and susceptibility of CRC.Due to the the quantity and the quality of documents,the above conclusions still need to carry out more research to be verified.
作者
沈瑶
熊远果
张洪
SHEN Yao;XIONG Yuanguo;ZHANG Hong(Department of Pharmacy,Renmin Hospital of Wuhan University,Wuhan 430060,China)
出处
《胃肠病学和肝病学杂志》
CAS
2018年第12期1386-1392,共7页
Chinese Journal of Gastroenterology and Hepatology
