摘要
目的分析HBV-DNA与乙型病毒性肝炎血清标志物的关系。方法根据HBV-DNA拷贝水平,将207例慢性乙型病毒性肝炎患者分成三组:低拷贝组(HBV-DNA 1×10~2～1×10~3 IU/ml)69例、中拷贝组(HBV-DNA 1×10~4～1×10~5 IU/ml)69例、高拷贝组(HBV-DNA≥1×10~6 IU/ml)69例,检测患者HBeAg、HBsAg、HBV大蛋白、AST和ALT水平,分析HBV-DNA与乙型病毒性肝炎血清标志物的关系。结果低拷贝组和中拷贝组HBeAg和HBsAg低于高拷贝组(P<0.01),低拷贝组AST和ALT低于中拷贝组和高拷贝组(P<0.01)。中拷贝组HBV-DNA与HBeAg呈负相关(r=-0.3429,P<0.05),与AST、ALT呈正相关(r=0.4579、0.4036,P<0.05);高拷贝组HBV-DNA与HBsAg呈正相关(r=0.3541,P<0.05)。结论 HBV-DNA与乙型病毒性肝炎血清标志物水平密切相关,可为乙型病毒性肝炎的病情判断提供依据。
Objective To investigate the relationship of HBV-DNA and the serum markers of hepatitis B.Methods According to HBV-DNA copy level,207 patients with chronic hepatitis B were divided into three groups of A(HBV-DNA=1×10~2-1×10~3 IU/ml,69 cases),B(HBV-DNA=1×10~4-1×10~5 IU/ml,69 cases)and C(HBV-DNA≥1×10~6 IU/ml,69 cases).Serum levels of HBeAg,HBsAg,HBV-LP,AST and ALT were detected and the relationship of HBV-DNA and serum markers of hepatitis B was analyzed.Results Serum levels of HBeAg and HBsAg were lower in groups of A and B than those in group C and AST and ALT were lower in group A than those in groups of B and C(P<0.01).HBV-DNA in group B was negatively correlated to HBeAg(r=-0.3429,P<0.05),and positively correlated to AST and ALT(r=0.4579 and 0.4036,P<0.05).HBV-DNA in group C was positively correlated to HBsAg(r=0.3541,P<0.05).Conclusion HBV-DNA is closely related to serum markers of hepatitis B,which may provide a basis for the evaluation of illness status of hepatitis B.
作者
马丽玲
徐俊驰
吴敏娟
王凤平
胥萍
MA Liling;XU Junchi;WU Minjuan(Inspection Center,Fifth People's Hospital of Suzhou ,Suzhou215007,CHINA)
出处
《江苏医药》
CAS
2018年第11期1279-1282,共4页
Jiangsu Medical Journal
基金
苏州市科技计划项目(SS201657)
