摘要
目的探索医用臭氧活化自血疗法辅助治疗支气管哮喘的临床价值。方法将100例哮喘患者作为研究对象,随机分为观察组(n=50)和对照组(n=50)。对照组采用常规治疗,观察组在对照组的基础上加用医用臭氧活化自血疗法。对比两组患者的治疗效果、血清不同白细胞介素(interleukin,IL)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、转化生长因子-β1(transforming growth factor-β1,TGF-β1)、血管内皮生长因子(vascular endothelial growth factor,VEGF)、呼出气一氧化氮(fractional exhaled nitric oxide,FeNO)和诱导痰嗜酸性粒细胞(eosinophils,EOS)%和不良反应。结果所有患者急性期症状均得到有效控制,出院至出院3个月期间,观察组有3例(6.00%)患者哮喘再次急性发作,对照组有10例(20.00%)患者哮喘再次急性发作,差异有统计学意义(x^2=4.332,P=0.037)。治疗后及治疗后3个月,观察组血清IL-6、IL-8、IL-13、TNF-α水平低于对照组,差异有统计学意义(P<0.05);治疗后及治疗后3个月,观察组血清TGF-β1、VEGF和Fe NO、EOS%水平低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率差异无统计学意义(x^2=0.260,P=0.610)。结论医用臭氧活化自血疗法可抑制哮喘患者气道炎症反应和气道重构,值得推广。
Objective To investigate the clinical value of auxiliary treatment of ozone-enriched autologous blood transfusion therapy on bronchial asthma. Methods A hundred patients with asthma admitted in the department of respiratory medicine were selected as the subjects,and randomly divided into observation group( n = 50) and control group( n = 50). The control group was treated with routine therapy,while the observation group was treated with ozone-enriched autologous blood transfusion therapy on the basis of the control group. The therapeutic effects,serum levels of different interleukin,tumor necrosis factor-α( TNF-α),transforming growth factor-β1( TGF-β1),vascular endothelial growth factor( VEGF),fractional exhaled nitric oxide( Fe NO),eosinophile granulocyte( EOS%) and the occurrence of adverse reactions were compared between the two groups. Results The acute symptoms of all patients were effectively controlled. During the first 3 months after,the recurrence rate of acute asthma attack in the observation group was6. 00%,which was significantly lower than that in the control group( 20. 00%,P < 0. 05). After treatment and 3 months after treatment,the levels of IL-6 IL-8,IL-13 and TNF-α in serum in the observation group were significantly lower than those in the control group( P < 0. 05). After treatment and 3 months after treatment,the levels of serum TGF-β1,VEGF,Fe NO and EOS% in the observation group were significantly lower than those in the control group( P < 0. 05).There was no significant difference in the incidence of adverse reactions between the two groups( P > 0. 05). Conclusion The ozone-enriched autologous blood transfusion therapy can reduce inflammation reaction and airway remodeling of patients with asthma.
作者
常清
刘待见
张铁栓
李珂
CHANG Qing;LIU Dai-fian;ZHANG Tie-shuan;LI Ke(Department ofRespiratory,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou450000,Henan,China)
出处
《广东医学》
CAS
2018年第21期3187-3191,共5页
Guangdong Medical Journal
基金
河南省科技发展计划项目(编号:162102310551)
