摘要
目的研究丹参多酚酸提取物的化学成分。方法利用各种色谱技术进行分离纯化,利用光谱技术进行化合物结构解析。结果从丹参多酚酸提取物中分离得到7个化合物,分别鉴定为(2R)-2-[(7-羟基-2-羰基-2,3-二氢苯并呋喃基)-(4→3)-2-(2E)-烯丙酰氧基]-3-(3,4-二羟基苯基)-丙酸(1)、丹酚酸D(2)、原儿茶醛(3)、迷迭香酸(4)、紫草酸(5)、丹酚酸B(6)和丹酚酸Y(7)。结论化合物1为新化合物,命名为丹酚酸D内酯。
Objective To investigate the chemical constituents from salvia polyphenolic acids.Methods Various column chromatographic techniques were used to separate and purify the chemical constituents and their structures were identified by spectral analysis.Results Seven compounds were isolated and obtained from salvia polyphenolic acids,which were identified as(2 R)-2-[(3-(7-hydroxy-2-oxo-2,3-dihydrobenzofuran-4-yl)-(2 E)-acryloyl) oxy]-3-(3,4-dihydroxyphenyl)-propanoic acid(1),salvianolic acid D(2),protocatechuic aldehyde(3),rosmarinic acid(4),lithospermic acid(5),salvianolic acid B(6),and salvianolic acid Y(7).Conclusion Compound 1 is a new compound,which is named as salvianolic acid D lactone.
作者
田介峰
阎红
王瑞静
李伟
岳洪水
罗学军
何毅
TIAN Jie-fengz;YAN Hong;WANG Rui-jing;LI Wei;YUE Hong-shui;LUO Xue-jun;HE Yi(TCM Research Center,Tasly Academy,Tasly Holding Group Co.,Ltd.,Tianjin 300410,China;State Key Laboratory of Critical Technology in Innovative Chinese Medicine,Tasly Pharmaceutical Group Co.,Ltd.,Tianjin 300410,China;Tasly Academy,Tasly Holding Group Co.,Ltd.,Tianjin 300410,China;Department of Techuology Development,Tianjin Tasly Pride Pharmaceutical Co.,Ltd.,Tianjin 300410,China)
出处
《中草药》
CAS
CSCD
北大核心
2018年第21期5024-5028,共5页
Chinese Traditional and Herbal Drugs
基金
国家科技重大专项重大新药创制项目"中医药优势领域的创新中药关键技术开发研究"(2017ZX09301005)
关键词
丹参多酚酸
丹酚酸D内酯
丹酚酸D
原儿茶醛
迷迭香酸
紫草酸
salvia polyphenolic acids
salvianolic acid D lactone
salvianolic acid D
protocatechuic aldehyde
rosmarinic acid
lithospermic acid
