摘要
目的探讨银杏叶提取物注射液辅助西药治疗急性脑梗死(ACI)疗效。方法将72例ACI患者随机均分为对照组和观察组,对照组参考指南给与基础与丁苯酞软胶囊治疗,观察组在对照组基础上加以银杏叶提取物注射液,治疗14 d后,比较两组中医疗效,治疗前后中医证候评分、神经功能改善评分(NIHSS)及自理能力改善评分(ADL)评分、外周血红细胞压积(HCT)、纤维蛋白原(FIB)、平均红细胞体积(MCV)、D-二聚体(D-D)、血清肌红蛋白(Myo)与载脂蛋白A1(Apo-A1)水平及血脂[总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)]水平变化。结果治疗后,两组中医证候积分中头晕目眩、半身不遂、偏身麻木、舌苔白腻均有显著降低(P<0.05),且治疗后观察组显著低于对照组(P<0.05);治疗后,观察组治疗总有效率为97.72%(35/36),显著高于对照组的77.78%(28/36),差异具有统计学意义(P<0.05);治疗后,两组NIHSS评分显著降低(P<0.05),ADL评分显著上升(P<0.05),且观察组治疗后与对照组差异有统计学意义(P<0.05);治疗后,两组外周血HCT、FIB、MCV、D-D水平显著降低(P<0.05),且观察组治疗后上述指标显著低于对照组(P<0.05);治疗后,两组Myo、Apo-A1水平显著降低(P<0.05),且观察组治疗后上述水平显著低于对照组(P<0.05);治疗后,两组TC、TG、LDL-C水平显著降低(P<0.05),且观察组治疗后上述水平显著低于对照组(P<0.05)。结论银杏叶提取物注射液联合西药治疗急性脑梗死具有良好的临床疗效,可改善中医证候、血液流动相关指标及脂代谢,促进神经功能与自理能力的恢复,值得推介。
Objective To explore the efficacy of Ginkgo Biloba Extract Injection supplemented with western medicine in the treatment of acute cerebral infarction(ACI).Methods Seventy-two patients with ACI were randomly divided into the control group and the observation group.The control group was given basal treatment and Butylphthalide Soft Capsule according to the guidelines,and the observation group was added with Ginkgo Biloba Extract Injection based on the control group.The TCM efficacy after 14 days of treatment,scores of TCM syndromes,scores of neurological function improvement(National Institutes of Health Stroke Scale,NIHSS)and self-care ability improvement(Activities of Daily Living,ADL),levels of peripheral blood hematocrit(HCT),fibrinogen(FIB),mean corpuscular volume(MCV),D-dimer(D-D),serum myoglobin(Myo)and apolipoprotein A1(Apo-A1)and blood lipids[total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C)]before and after treatment were compared between the two groups.Results After treatment,the scores of TCM syndromes such as dizziness,hemiplegia,hemianesthesia and whitish greasy coating in the two groups were significantly reduced(P<0.05),and the scores of the observation group after treatment were significantly lower than those of the control group(P<0.05).After treatment,the total effective rate in the observation group(97.72%,35/36)was significantly higher than that(77.78%,28/36)in the control group(P<0.05).After treatment,the NIHSS scores of the two groups were significantly decreased(P<0.05)while the ADL scores were significantly increased(P<0.05),and the scores of the observation group were significantly different from those of the control group after treatment(P<0.05).After treatment,the levels of peripheral blood HCT,FIB,MCV and D-D were significantly reduced in the two groups(P<0.05),and the above indicators in the observation group after treatment were significantly lower than those in the control group(P<0.05).The levels of Myo and Apo-A1 in the two groups were significantly
作者
王亚飞
WANG Yafei(Department of Internal Medicine,Tongzhou District Hospital of Integrated Traditional Chinese and Western Medicine,Beijing 101100,China)
出处
《辽宁中医杂志》
CAS
2022年第5期131-135,共5页
Liaoning Journal of Traditional Chinese Medicine
