摘要
目的:观察银杏叶提取物注射液联合依达拉奉治疗急性脑梗死(ACI)患者的效果。方法:选取2022年2—9月该院收治的88例ACI患者进行前瞻性研究,按照随机数字表法将其分为观察组和对照组各44例。两组均予以常规治疗,在此基础上,对照组予以依达拉奉治疗,观察组在对照组基础上联合银杏叶提取物注射液治疗,两组均连续治疗14 d。比较两组临床疗效,治疗前后神经功能缺损[美国国立卫生研究院卒中量表(NIHSS)]评分、血液流变学指标[血浆黏度(PV)、全血低切黏度(LBV)、全血高切黏度(HBV)]水平,以及不良反应发生率。结果:观察组治疗总有效率为95.45%(42/44),高于对照组的68.18%(30/44),差异有统计学意义(P<0.05);治疗后,观察组NIHSS评分和PV、LBV、HBV水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:银杏叶提取物注射液联合依达拉奉治疗ACI患者可提高治疗总有效率,降低NIHSS评分和血液流变学指标水平,效果优于单纯依达拉奉治疗。
Objective:To observe effects of extract of Ginkgo biloba leaves injection combined with Edaravone in treatment of patients with acute cerebral infarction(ACI).Methods:A prospective study was conducted on 88 patients with ACI admitted to this hospital from February to September 2022.They were divided into observation group and control group according to the random number table method,44 cases in each.Both groups were given routine treatment.On this basis,the control group was treated with Edaravone,while the observation group was treated with extract of Ginkgo biloba leaves injection on the basis of that of the control group.Both groups were treated for 14 d.The clinical efficacy,the neurological deficit[National Institutes of Health stroke scale(NIHSS)]score,the hemorheology index levels[plasma viscosity(PV),whole blood low shear viscosity(LBV),whole blood high shear viscosity(HBV)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 95.45%(42/44),which was higher than 68.18%(30/44)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the NIHSS score and the PV,LBV and HBV levels in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Extract of Ginkgo biloba leaves injection combined with Edaravone in the treatment of the ACI patients can improve the total effective rate of treatment and reduce the NIHSS scores and the hemorheology index levels.Moreover,it is superior to single Edaravone treatment.
作者
闫如冰
张卫星
YAN Rubing;ZHANG Weixing(1^(st) Department of Neurology of the Fourth People’s Hospital of Shangqiu City,Shangqiu 476000 Henan,China)
出处
《中国民康医学》
2023年第23期35-37,共3页
Medical Journal of Chinese People’s Health
关键词
急性脑梗死
银杏叶提取物注射液
依达拉奉
血液流变学
神经功能缺损
不良反应
Acute cerebral infarction
Extract of Ginkgo biloba leaves injection
Edaravone
Hemorheology
Neurological deficits
Adverse reaction
