摘要
目的 应用Bayesian反馈法预测头孢唑啉在老年患者体内的药动学参数及血药浓度。方法 用HPLC测定头孢唑啉血药浓度。以 1,2个实测血药浓度作为反馈 ,用Bayesian反馈法拟合估算老年患者的个体药动学参数 ,并与非老年患者比较。结果 老年组 10例的CL为 (6 0 .1± 17.3)mL·h-1·kg-1,Vd 为 (0 .2 1± 0 .0 7)L·kg-1,t1/ 2 为 (2 .6± 0 .8)h ;非老年组 10例分别为CL(87.6± 34 .4)mL·h-1·kg-1,Vd(0 .19± 0 .0 8)L·kg-1和t1/ 2 (1.5± 0 .4)h。二组CL ,t1/ 2 之间的差异有显著意义 (P <0 .0 5 ) ,Vd之间差异则无显著意义 (P >0 .0 5 )。血药浓度预测值与实测值有良好的相关性 (r=0 .997)。结论 老年患者随增龄CL降低 ,t1/ 2 延长 ,而Vd不变。
OBJECTIVE: To forecast the individual pharmacokinetic parameters of cefazolin in elderly patients with infecton by Bayesian approach. METHODS: The cefazolin concentration in serum was measured by HPLC. Using 1 or 2 measured drug concentrations, the individual pharmacokinetic parameters were estimated by Bayesian feedback method, and then compared with those of non-elderly patients. RESULTS: The pharmacokinetic parameters in 10 elderly and 10 non-elderly were CL(60.1 ± 17.3), (87.6 ± 34.4) mL · h-1 · kg-1, Vd(0.21 ± 0.07), (0.19 ± 0.08) L · kg-1, t1/2 (2.6 ± 0.8), (1.5 ± 0.4) h, respectively. There was significant difference in CL and t1/2 parameters between the two groups (P d parameter (P > 0.05). CONCLUSION: The pharmacokinetic parameters estimated by Bayesian approach was similar compared with the parameters eatimated by traditional method. It is suitable for forecasting plasma concentration and optimizing individualizing dosage regimens.
出处
《中国药学杂志》
EI
CAS
CSCD
北大核心
2001年第7期465-467,共3页
Chinese Pharmaceutical Journal
