摘要
本文提出了口服氨茶碱后以Bayesian反馈法取一点血药浓度制订个体化给药方案的方法,对本院收治的10例慢性阻塞性肺病(COPD)和10例一般哮喘患者口服氨茶碱后的药动学参数做比较,结果表明:COPD的清除率为27.43±3.70ml·kg^(-1)h^(-1),哮喘患者为40.56±1.37ml·kg^(-1)·h^(-1),半衰期COPD为13.37±2.12h,哮喘为9.59±3.10h。两组患者的清除率有显著性差异(P<0.05),提示:在给药方案设计时,必须个体化。本文运用Bayesian一点反馈法对6例病人的用药进行了调整,其结果比较满意。
Bayesian feedback method was used in in-dividualizing theophylline dosage schedue. In-dividual pharmacokinetic parameters were pre-dicted through one point of theophylline serumdrug concentration. In asthma patients, theclearance (CL) of theophylline was 27. 43±3.70ml·kg^(-1)·h^(-1), the elimination half life oftheophylline (t_(1/2)) was 13.37±2.17h, whereasin COPD patients, CL was 40.56±1.37ml·kg^(-1)·h^(-1), t_(1/2)9.59±3.10h, The results not on-ly showed that CL has significant difference inthe two groups (P<0.05), but also indicatedthat individualizing dosage schedue is neces-sary in routine of the ophylline clinical moni-toring.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1993年第7期401-403,共3页
Chinese Pharmaceutical Journal
基金
国家自然基金课题 39070946
关键词
氨茶碱
反馈法
哮喘
血液
theophyllines
bayesian feedback method
serum drug concentrations
asthma
chromic obstructive plumonary disease
