摘要
目的用Bayesian反馈法估算临床患者静脉输注伏立康唑的群体药动学(PPK)参数。方法收集静脉输注给药不同时间后的血样,采用HPLC法测定伏立康唑血药浓度,用Bayesian反馈法估算PPK参数。结果以二室模型拟合伏立康唑的药动学过程,得PPK参数为Vss为(46.58±19.35)L,CL为(4.76±2.64)L/h,k10为(0.187±0.006)h-1k,12为(4.97±0.02)h-1,k21为(0.895±0.308)h-1。结论此PPK模型能够较准确地描述伏立康唑在临床患者静脉输注的药动学特征,其预测能力尚待进一步评估。
Objective To study the population pharmacokinetics（PPK） of voriconazole in clinical patients after intravenous infusion by Bayesian feedback method.Methods A HPLC method was set up to determine the levels of voriconazole in plasma at different time points after intravenous infusion administration.PPK parameters of voriconazole were estimated by Bayesian feedback method.Results The pharmacokinetic process of voriconazole was described by a linear two-compartment model,the estimated PPK parameters of Vss,CL,k10,k12,k21 were（46.58±19.35）L,（4.76±2.64）L/h,（0.187±0.006）h-1,（4.97±0.02）h-1,（0.895±0.308）h-1,respectively.Conclusion The PPK model built describes the pharmacokinetic process of voriconazole after intravenous infusion in clinical patients adequately.The prediction performance of the PPK model needs further assessment.
出处
《今日药学》
CAS
2011年第1期18-19,52,共3页
Pharmacy Today
基金
广东省医院药学研究基金(编号:2010A19)
