摘要
目的 :观察不同类型心绞痛患者血浆内皮素 (ET)的变化 ,探讨它与冠脉病史和射血分数的关系。方法 :30例心绞痛患者 ,按照临床表现和冠脉狭窄程度分为 :稳定型心绞痛 (SAP)和不稳定型心绞痛 (U AP)组 ;轻度狭窄、中度狭窄和重度狭窄组。结果 :UAP血浆 ET显著高于 SAP和正常对照组 (P<0 .0 1) ,而 SAP与正常对照组无差异(P>0 .0 5 ) ;随着冠脉狭窄程度加重 ,血浆 ET有增高趋势。重度狭窄组显著高于轻度和中度狭窄组 (P<0 .0 5或 P<0 .0 1)。结论 :血浆 ET水平与冠脉病变积分呈正相关 (r=0 .5 2 4,P<0 .0 1) ,而与左室射血分数呈负相关 (r=-0 .496 ,P<0 .0 1)。
AIM:To assess the changes of plasma ET level and relationshop with the severity of left ventriuclar ejection fraction(LVEF) and clinical presentation in varied coronary artery disease(CAD). METHODS:30 cases with either stable angina(SAP) or unstable angina(UAP),were performed with coronary angiography(CAG). According to the feature of angina pectoris and unequivocal evidence of arterial narrowing,the patients were classified into:①SAP group and UAP group and ② mild,middle-and severe-narrowed artery groups. The samples were drawn before CAG. RESULTS:The levels of plasma ET were higher in the UAP group compared with the control group (P<0.01),but the plasma ET level in the SAP group was no significant difference with the control group(P>0.05). The plasma ET levels increased in accordance with the degree of the coronary artery narrowing. The plasma ET level of the patients with severe-narrowed artery was higher than that of the mild and middle-narrowed (P<0.05, or P<0.01). The middle-narrowed group was higher than that of the control group(P<0.01). The plasma ET level tended to increase in middle-narrowed group,but the change was no significant statistically. The plasma ET level showed a positive correlation with the coronary abnormality index(r=0.524,P<0.01) and negative correlation with LVEF(r=-0.496,P<0.01). CONCLUSION:The levels of plasma ET will be associated with the clinical presentation,and the degree of coronary artery narrowing. The more coronary vessels affected as well as the worse ventricular function,the higher the plasma ET levels were. It indicates that the plasma ET can reflect the severity of CAD and be used as an indicator for the severity and the prognosis of the CAD.
出处
《心脏杂志》
CAS
2001年第5期383-384,387,共2页
Chinese Heart Journal
