摘要
目的 :制备口恶丙嗪乳胶剂 ,建立其含量测定的方法并对其抗炎作用进行考察。方法 :以卡波姆 - 94 0作为乳胶基质 ,制备口恶丙嗪乳胶剂。用紫外分光光度法测定含量。测定波长 (2 87± 1nm ) ,以小鼠耳壳致炎实验评价其疗效。结果 :平均回收率为 99.5 9% ,RSD为 1.2 6 % ,小鼠耳壳肿胀度为 :1.92± 0 .5 mg。结论 :本制剂制备容易 ,性质稳定 ,测定方法简单、快速。动物实验表明
OBJECTIVE: To prepare oxprozion emultion, establish an UV spectrophotometry for the determination of oxprozion emlsion and observe the anti inflammation effect. METHODS: The oxprozion emulsion with Carbomer 940 as excipient was assayed by an UV spectrophotometry at 287±1 nm. The effect was valued by inflammatory trial of mice ear. RESULTS: The average recovery was 99.59%. (RSD=1.26%). The rate of mice ear swelling was 1.92±0.5mg. CONCLUSIONS: The preparation of oxprozion emulsion was simple and its quality was stable. The determination method was rapid. In animal trials, the results were shown to be highly effective in anti inflammation.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2001年第6期462-463,共2页
Chinese Journal of Modern Applied Pharmacy
