摘要
给动物灌服(口恶)丙嗪,表明该药能抑制角叉菜胶、巴豆油所致的小鼠渗出性炎症和棉球所致的肉芽肿增生,对大鼠佐剂性关节炎有明显的抑制作用,可降低毛细血管通透性,抑制白细胞游走反应,其抗炎作用与肾上腺无直接关系。该药抗炎作用强度与阿司匹林相似,但作用时间明显延长。
The antiinflammatory activity of oxaprozin was studied.The
results showed that oxaprozin inhibitd the exudative inflammation induced
by croton oil or carrageenan and the granuloma tissue formation induced by
cotton pellet.The acute antiinflammatory effect was independent of pitui-
tary-adrenal axis.The agent had therapeutic action on the adjuvant arthritis
of rats.The effects of oxaprozin at 200mg/kg appeared similar to those of
aspirin at the same dose,but its effects lasted longer.
出处
《山东医科大学学报》
1993年第1期68-70,共3页
Acta Academiae Medicinae Shandong
关键词
E丙嗪
炎症
药理学
乙酰水杨酸
Oxaprozin
Aspirin
Inflammation
Pharmacology
Animals
