摘要
目的：探讨弥漫性甲状腺肿伴甲亢（Ｇｒａｖｅｓ病）患者的氧化／抗氧化平衡紊乱以及抗甲状腺药物内基硫氧嘧啶（ＰＴＵ）治疗的影响。方法：检测３２例Ｇｒａｖｅｓ病患者治疗前后血浆脂质过氧化物（Ｐ－ＬＰＯ）、红细胞内超氧化物歧化酶（Ｅ－ＳＯＤ）、谷胱甘肽过氧化物酶（Ｅ－ＧＰｘ）、过氧化氢酶（Ｅ－ＣＡＴ）的浓度变化。结果：与正常对照组比较，Ｇｒａｖｅｓ病患者Ｐ－ＬＰＯ明显升·高（９．８６±２．０６ｍｍｏｌ·Ｌ－１ｖｓ ５．６４±８２ｍｍｏｌ·Ｌ－１Ｐ＜０．０１）、Ｅ－ＳＯＤ、Ｅ－ＧＰｘ、Ｅ－ＣＡＴ也明显升高（Ｐ＜０．０５－０．０１），经ＰＴＵ治疗一个月后均有明显下降（Ｐ＜０．０５－０．０１）。结论：Ｇｒａｅｓ病患者氧化应激增加，抗甲状腺药物ＰＴＵ起着一定的抗氧化作用。
OBJECTIVE: To study the oxidant/antioxidant status of Graves'disease and effect ofpropylthiouracil(PTU)on it. METHODS: Plasma lipid peroxide(P-LPO). and superoxide dismutase(SOD), glutathione peroxidase(GPx), catalase(CAT) in erythrocytes in 32 Graves isease before and after treatment with PTU were measured. RESULTS: Compared with the control group, P-LPO content in Graves'disease was significantly increased(9.86 ±2.O6mmol.L-1vs 5.64±1.82mmol.L-1P<O.O 1). E- SOD. E-GPx、E-CAT were significantly higher(P<O.O5-P0.O1), the levels of them were normal after a month administration with PTU. CONCLUSION: There were disturbed balance between oxidative and antioxidative in Graves'disease with hyperthyroidism. PTU was protective against the oxidative stress.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2001年第6期431-433,共3页
The Chinese Journal of Clinical Pharmacology
