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核受体PXR、CAR、LXR和FXR作为代谢性疾病治疗靶点的研究进展 被引量：7

Nuclear receptors PXR,CAR,LXR and FXR as therapeutic targets of metabolic diseases:research advance
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摘要 PXR、CAR、LXR和FXR是核受体家族的重要成员,在体内广泛分布,经配体活化后调控众多机体代谢相关的酶、转运蛋白和信号途径,在糖异生、脂类代谢及其胆汁平衡中扮演着重要的角色。通过主要介绍核受体家族主要成员PXR、CAR、LXR和FXR在糖异生、脂类代谢以及胆汁平衡中的调控作用,从而可能为糖脂代谢和胆汁平衡紊乱相关代谢性疾病的药物治疗提供新依据。 PXR,CAR,LXR and FXR,widely distributed in the body,are important members of nuclear receptors（NRs）family.Metabolism related enzymes,transporter protein and signal pathways can be regulated by the activated NRs,which play important roles in gluconeogenesis,lipid metabolism and bile homeostasis.This review described the research progress of NR family members PXR,CAR,FXR and LXR,and regulating effects of gluconeogenesis,lipid metabolism and bile homeostasis,which might provide a new reference for clinical medication of metabolic diseases.
作者 马彦荣 张国强 武新安
机构地区 兰州大学第一医院药剂科 兰州大学药学院
出处 《中国医院药学杂志》 CAS CSCD 北大核心 2015年第7期659-663,共5页 Chinese Journal of Hospital Pharmacy
关键词 核受体 代谢性疾病 靶点 糖异生 脂类代谢 胆汁平衡 nuclear receptor metabolic diseases targets gluconeogenesis lipid metabolism bile homeostasis
分类号 R969 [医药卫生—药理学]
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参考文献42

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中国医院药学杂志
2015年 第7期

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