摘要
目的 探讨不稳定性心绞痛 (UAP)患者cTnI定量检测同冠脉病变数量、程度和预后之间的关系。方法 不稳定性心绞痛患者 6 8例 ,采用美国DPC公司全自动化学发光免疫检测系统及试剂进行血清cTnI定量检测、CK MB质量试验。并行冠脉造影术。随访观察 30天后心脏事件的发生。结果 6 8例UAP患者中 ,A组 2 6例 (占 38 2 % ) ,cTnI≥ 0 4ng/ml。B组 42例 (占 6 1 8% ) ,cTnI <0 4ng/ml。同步测定CK MB质量 ,二组间差异无显著性。A组中C型病变、三支病变、左主干受累和高度狭窄 2 0例 (占 76 9% ) ,明显高于B组 9例 (占 2 1 4% ,P <0 0 5 )。A组Braunwald分级ⅢA或ⅢB者 2 3例 (占 88 5 % ) ,B组仅 3例 (占 7 1% ) ,明显高于B组 (P <0 0 0 1)。A组 30天内发生心脏事件 14例(占 5 3 8% ) ,明显高于B组 4例 (占 9 5 % ,P <0 0 1)。结论 化学发光免疫分析法cTnI定量检测同冠状动脉病变数量及严重程度、临床Braunwald分级有密切关系。
Objective To make out the relationship between the serum cardiac troponin I and the severity and extent of coronary lesions in unstable angina pectoris and the prognosis in unstable angina pectoria Methods Serum cTnI and CK MB were measured with Automated montinuous random access chemiluminescent immunoassay system and reagent of DPC inc USA in 68 patients with UAP,and coronary angiography was given, observe the rate of the cardiac accident after 30 days Results Among 68 UAP patients,In group A,26 cases (38 2%), cTnI≥0 4 ng/ml In group B,42 cases (61 8%), cTnI<0 4 ng/ml There is no remarkable difference between group A and group B when we measured their serum CK MB In group A, there is 20 cases (76 9%) with type C lesions, frequent triple vessel and left main coronary artery involvement, and higher mean percentage diameter stenosis in the coronary arteries than those in group A, 9 cases (21 4%, P <0 05) In group A, there is 23 cases experienced Braunwald′s class Ⅲ (A and B) unstable angina (88 5%),there is only 3 cases (7 1%) It is remarkable higher in group A than in group B ( P <0 001) There is 14 cardiac accidents in group A,which is higher than group B (4 cases, 9 5% P <0 01) Conclusion Chemiluminescent immunoassay testing, elevated values of serum cardiac troponin I to be evenly associated with the severity and extent of coronary lesions, as well as the clinical severity of unstable angina It could predict the prognosis of patients with unstable angina
出处
《中国介入心脏病学杂志》
2001年第B12期64-66,共3页
Chinese Journal of Interventional Cardiology
