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经胸体外单、双相波除颤对犬心肌损伤的程度比较 被引量:3

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摘要 目的比较经胸体外单、双相波除颤对犬心肌的损伤程度。方法健康成年杂种犬13只,随机分为单相波除颤组(A组)7只、双相波除颤组(B组)6只。两组均经右颈外静脉置管至右心室诱发室颤,15 s后给予除颤。除颤前后记录Ⅱ导联ST段改变情况;用ELISA法测定每组除颤前及窦性心律恢复后15、30、60 m in血清心型脂肪酸结合蛋白(H-FABP)含量,除颤前及窦性心律恢复后4、6、8 h血清肌钙蛋白I(cTnI)含量;观察72 h后心脏病理形态学改变。结果 A组6只ST段明显压低或抬高,有的伴有T波倒置;B组1只发生ST段上斜性压低,且很快恢复到基线水平,两组比较有统计学意义(P=0.029)。两组除颤后H-FABP立即升高,15 m in达高峰,30 m in已下降,B组与A组相比各时间点均明显降低(P<0.05)。cTnI除颤后4 h已出现,并呈上升趋势,8 h后B组明显低于A组(P<0.01)。与A组相比,B组心脏损伤病理学改变明显减轻。结论除颤能量与次数相同的情况下,双相波除颤引发的心肌损伤较单相波除颤轻。
出处 《山东医药》 CAS 北大核心 2010年第41期36-37,共2页 Shandong Medical Journal
基金 江西省卫生厅科技计划(20063065)
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