摘要
目的：以卡波姆、羟丙甲基纤维素等辅料制备阿莫西林胃滞留片。方法：采用正交设计，以释放度和漂浮性为考察指标进行处方筛选。结果：以处方5为最佳处方制得的片剂具有较好的漂浮与缓释效果，稳定性研究表明，该胃滞留片 的稳定性良好。 结论：本研究制备的阿莫西林胃滞留片具有缓释、起漂时间快、稳定性好的特点。
：OBJECTIVE To make amoxicillin gastric residential tablets by using carbopol and hydroxypro pylmethylcellose(HPMC). METHODS By orthogonal design, each formulation was evaluated using releasing rate and floating ability as index an d its stability properties were studied. RESULTS Formulation 5 had good floating and slow releasing rate. The stability test resu lts showed that the tablets we re stable under the test conditions. CONCLUSIONS The tablets prepared had good slow releasing rate, short afloating time and good stability.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2001年第9期526-528,共3页
Chinese Journal of Hospital Pharmacy
