摘要
目的 :探讨肺癌中细胞周期调控因子p16和CDK4的表达意义。方法 :应用S P免疫组织化学方法检测 6 2例肺癌组织中p16和CDK4的表达情况。结果 :6 2例肺癌组织中p16和CDK4阳性率分别为 5 8 1%和 48 4%。腺癌中p16的阳性率明显高于小细胞癌 (P <0 0 5 ) ;淋巴结转移阳性组p16的表达显著低于阴性组 (P <0 0 5 ,r =0 2 7)。不同组织类型肺癌中CDK4的表达未见明显差异 ,淋巴结转移阳性组CDK4的表达高于阴性组 (P <0 0 1,r=0 5 8)。p16和CDK4的表达呈明显负相关 (P <0 0 1,r =- 0 81)。结论 :提示p16的表达与肺癌的组织学类型有关 ,CDK4高表达对肺癌细胞的淋巴结转移起重要作用。
Purpose:To study the expressions of p16 and CDK4 in human lung carcinoma. Methods:By using S-P immunohistochemical methods, the expressions of p16 and CDK4 in 62 cases of human lung carcnoma were studied. Results:The postive expressions for p16 and CDK4 protein were 58.1% and 48.4% respectively. A significant correlation was found between CDK4 overexpression and lymph node metastasis ( P <0 01). A significant correlation between the under expression of p16 and overexpression of CDK4 was found.Conclusions:The results suggested that CDK4 overexpression plays an important role in metastasis of lung carcinoma.
出处
《中国癌症杂志》
CAS
CSCD
2001年第2期123-124,共2页
China Oncology
基金
江西省卫生厅科研基金 (No.980 0 2 1)资助
