摘要
目的 :研究知母皂苷 (SAaB)对衰老大鼠脑乙酰胆碱受体的影响。方法 :采用放射受体配体结合实验 ,测定大鼠脑皮层M ,N受体的密度及亲和力。结果 :与正常成年大鼠比较 ,衰老大鼠大脑皮层M受体的密度和亲和力无明显变化 ,而脑N受体的密度显著减少 ;SAaB能剂量依赖性地增加衰老大鼠脑N受体的数目 ,对M受体无明显影响。结论
Aim To study the effects of saponins from Anemarrhena asphodeloides Bge.(SAaB) on cerebral acetylcholine receptors in aged rats.Methods Cerebral muscarinic(M) and nicotinic(N) receptors were measured by radioligand receptor binding assay.Rats were po administered with SAaB for 15d.Results Compared with normal rats,the densities of cerebral N receptors in aged rats were decreased significantly.SAaB(15.0,25.0,and 40.0mg·kg -1 ,po) could increase cerebral N receptors in a dose dependent manner,however,it had no remarkable effects on M receptors.Conclusion SAaB can enhance the cerebral N receptors of aged rats.
出处
《解放军药学学报》
CAS
2001年第2期71-72,共2页
Pharmaceutical Journal of Chinese People's Liberation Army
关键词
知母皂苷
受体
乙酰胆碱
脑
Anemarrhena asphodeloides Bge
Saponins
Acetylcholine receptors
Cerebra
