摘要
目的探讨大豆甙元对超重并肥胖人群的心血管疾病危险因素的影响。方法采用随机对照临床试验,从重庆市某三甲医院筛选80例体质量指数(BMI)>24kg/m2的高胆固醇血症患者为受试对象,分为试验组和对照组,每组40例。试验组每日服用含80mg大豆甙元的大豆分离蛋白粉5g,对照组服用不含大豆异黄酮的大豆分离蛋白粉5g,干预时间为6个月。服用前后测定心血管疾病危险因素相关指标。结果干预后试验组BMI下降,下降率为3.81%,自身干预前后比较差异有统计学意义(P<0.01);血清中总胆固醇(TC)下降,下降率为10.11%,自身干预前后比较差异有统计学意义(P<0.01),与对照组比较差异有统计学意义(P<0.05);糖化血红蛋白(HbA1c)下降,下降率为13.91%,自身干预前后比较差异有统计学意义(P<0.01),与对照组比较差异有统计学意义(P<0.05);血糖(Glu)下降,下降率为0.76%,自身干预前后比较差异有统计学意义(P<0.01)。血常规、肝功能、肾功等安全性指标干预前后均无明显改变。结论大豆甙元能降低高胆固醇血症患者BMI、TC、HbA1c、Glu等心血管疾病危险因素。
Objective To investigate the effects of daidzein on the risk factors of cardiovascular disease（CVD）in overweight and obesity population.Methods Using the randomized controlled clinical trial,80 hypercholesterolemia patients with BMI＆gt;24 kg/m2 were screened as the study subjects from a class 3A hospital in Chongqing and randomly divided into the experimental group and the control group,40 cases in each group.The experimental group took isolated soy protein powder 5 g containing daidzein 80 mg every day and the control group only took isolated soy protein powder 5 g without containing isoflavones.The intervention time was 6 months.The CVD related risk factors and safety indexes were assessed before and after intervention.Results After 6-month in-tervention,BMI was decreased with the descent rate of 3.81%,the difference between before and after self intervention had statisti-cal significance（P〈0.01）;serum total cholesterol（TC）was decreased with the descent rate of 10.11%,the difference between be-fore and after self intervention had statistical significance（P〈0.01）,compared with the control group,the difference had statistical significance（P〈0.05）;glycated hemoglobin（HbA1c）was decreased with the descent rate of 13.91%,the difference between be-fore and after self intervention had statistical significance（P〈0.01）,compared with the control group,the difference had statistical significance（P〈0.05）;blood glucose（Glu）was decreased with the descent rate of 0.76%,the difference between before and after self intervention had statistical significance（P〈0.01）.The safety indexes in blood routine,liver function and renal function had no obvious changes before and after intervention.Conclusion Daidzein could decrease the CVD risk factors,such as BMI,TC,HbA1c and Glu.
出处
《重庆医学》
CAS
CSCD
北大核心
2014年第17期2116-2118,共3页
Chongqing medicine
基金
国家自然科学基金资助项目(81072288)
重庆市重点攻关项目(CSTC.2011AB5040)
关键词
大豆甙元
肥胖
心血管疾病
daidzein
obesity
cardiovascular-disease
