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平均血小板体积在健康及空腹血糖受损人群中分布水平的研究 被引量:13

Distribution of mean platelet volume in the healthy and impaired fasting glucose individuals
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摘要 目的:探讨平均血小板体积( MPV)在空腹血糖( FPG)正常的健康人群及空腹血糖受损( IFG)人群中的分布差异及其临床意义。方法对2012年5至7月天津市环湖医院499名健康体检者数据进行回顾性分析,年龄35~80岁,平均45岁,男184名,女315名。根据FPG水平将其分为4组( G1~G4):G1组125名(3.89 mmol/L≤FPG <5 mmol/L ), G2组121名(5 mmol/L≤FPG <5.5 mmol/L),G3组142名(5.5 mmol/L≤FPG<6.1 mmol/L ), G4组111名(6.1 mmol/L≤FPG<7 mmol/L),其中G1~G3为正常血糖组,G4为IFG组;同时平行观察89例同年龄段确诊Ⅱ型糖尿病组( G5)。结果 MPV 值随 FPG 水平升高而升高, G1~G5组 MPV 值分别为(8.62±0.77) fl、(8.85±0.80) fl、(8.90±0.69) fl、(9.14±0.78) fl 和(12.03±1.42) fl;糖尿病组(G5)MPV 值[(12.03±1.42) fl]显著高于IFG组(G4)[(9.14±0.78) fl]和正常血糖组[G1(8.62±0.77) fl、G2(8.85±0.80) fl、G3(8.90±0.69) fl](F=12.773,P<0.01);IFG组(G4)MPV值[(9.14±0.78) fl]显著高于正常血糖组[G1(8.62±0.77) fl、G2(8.85±0.80) fl、G3(8.90±0.69) fl](F=12.773,G4较G1和G2, P<0.01; G4较 G3,P<0.05);正常血糖组中,较高血糖组G3的MPV值[(8.90±0.69) fl]明显高于较低血糖组G1[(8.62±0.77) fl],F=12.773,P<0.05;MPV与正常血糖组、IFG组及糖尿病组的FPG均显示一定相关性( G1~3:r=0.22,P<0.05;G4:r=0.26,P<0.01;G5:r=0.29,P<0.01)。结论 MPV水平在不同FPG水平人群中表达存在明显差异,其中IFG组MPV水平较正常血糖组显著升高,MPV与FPG水平存在相关性。(中华检验医学杂志,2014,37:451-454) Objective The different distribution and clinical significance of mean platelet volume (MPV) in the healthy normoglycemic and impaired fasting glucose (IFG) individuals were discussed.Methods The 499 individuals including 184 male and 315 female,who had undergone health checks in Tianjin Huanhu Hospital during May and July 2012 were studied retrospectively.Average age is forty-five ( thirty-five to eighty).Subjects were categorized into four groups according to fasting plasma glucose ( FPG) levels:G1 (3.89 mmol/L≤FPG〈5 mmol/L, n=125),G2(5 mmol/L≤FPG 〈5.5 mmol/L, n=121), G3(5.5 mmol/L≤FPG〈6.1 mmol/L, n=142), and G4(6.1 mmol/L≤FPG〈7 mmol/L, n=111).G1, G2, and G3 are defined as normal FPG groups and G 4 is defined as IFG group.Eighty-nine cases in the same age patients with type II diabetes mellitus group ( G5 ) were observed at the same time.Results The MPV increased with the increasing FPG levels in the following order:G1(8.62 ±0.77) fl, G2 (8.85 ±0.80) fl, G3(8.90 ±0.69) fl,G4(9.14 ±0.78) fl and G5(12.03 ±1.42) fl.MPV[(12.03 ±1.42) fl] of type Ⅱdiabetes mellitus group(G5) was higher than that in the IFG group (G4)[(9.14 ±0.78) fl] and normal FPG groups[G1(8.62 ±0.77) fl,G2(8.85 ±0.80) fl,G3(8.90 ±0.69) fl] (F=12.773,P〈0.01);MPV of the IFG group [ ( 9.14 ±0.78 ) fl ] was significantly higher than that in normal FPG groups [ G1 (8.62 ±0.77) fl,G2(8.85 ±0.80) fl,G3(8.90 ±0.69) fl] (F=12.773,P〈0.01 for G4 vs.G1 and G2, P〈0.05 for G4 vs.G3) ;MPV in the high-normal glucose group (G3) [(8.90 ±0.69) fl] was obviously higher than that in the low-normal glucose group (G1) [(8.62 ±0.77) fl] (F=12.773,P〈0.05);MPV was positively associated with FPG in normal FPG groups ,IFG group and type Ⅱ diabetes mellitus group (G1-3:r=0.22, P〈0.05;G4:r=0.26, P〈0.01;G5:r=0.29, P〈0.01).Conclusions Significant difference of MPV was observed in po
出处 《中华检验医学杂志》 CAS CSCD 北大核心 2014年第6期451-454,共4页 Chinese Journal of Laboratory Medicine
基金 天津市科技支撑计划项目资助课题(13ZCZDSY01600)
关键词 平均血小板体积 血糖 糖尿病 2型 Mean platelet volume Blood glucose Diabetes mellitus,type 2
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参考文献16

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二级参考文献30

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