摘要
目的：评价大剂量丙种球蛋白联合甲基强的松龙治疗急性吉兰-巴雷综合征的临床疗效及安全性。方法选择我院收治的44例急性吉兰-巴雷综合征患者，随机分为A、B组各22例，A组给予维生素B1、B6、B12、能量合剂及抗生素，并保持患者呼吸道通.及重症监护措施，同时，每日静滴丙种球蛋白，剂量为0.4 g·kg-1，连续治疗5 d。B组在A组治疗的基础上，加用15～20 mg ·kg-1甲基强的松龙，连续应用5 d。对比分析2组患者的起效时间、住院时间、临床疗效，并观察治疗过程中不良反应。结果2组患者的起效时间比较差异无统计学意义（P＞0.05），B组患者的住院时间显著少于A组，差异有统计学意义（ P＜0.05）。B组总有效率（95.45％）显著高于A组（63.64％，P＜0.05）。2组患者治疗过程中均出现心慌、恶心、发热等症状，给予减慢滴注速率或物理降温措施后，患者症状减轻或消失。结论大剂量丙种球蛋白联合甲基强的松龙治疗急性吉兰-巴雷综合征疗效显著，与单用大剂量丙种球蛋白比较，能显著缩短住院时间，且用药安全性好，无严重不良反应。
Objective To evaluate the clinical efficacy and security of high dose of gamma globulin combined with methyl-prednisolone in the treatment of acute Guillain-Barre syndrome. Methods Foety-four cases of acute Guillain-Barre syndrome in our hospitail were divided into A and B group randomly ,with 22 cases in each group. Patients in group A were given antibiotic and vitaminB1 ,B6 and B12 ,were cared intensively ,respiratary tract were kept clear. At the same time ,patients were given intra-venous drip of gamma globulin ,the dose was 0.4 g ＆#183; kg-1 for 5 days. Patients in group B were given methylprednisolone 15-20 mg ＆#183; kg-1 for 5 days on the basis of group A. The onset time ,length of stay ,clinical efficacy of two groups were analyzed ,ad-verse reactions were observed.Results There were no statistical significances between the two groups in the onset time （P〉0.05） ,the hospital stay of group B was shorter than group A ,the difference was significant （P〈0.05）. The efficacy of group B （95.45% ）was higher than that of group A significantly （63.64% ,P〈0.05）. Palpitation ,nausea ,fever and other symptoms were occurred in both groups ,symptom decreased after dripping rate was slowed down or patients were given physical tempera-ture lowering. Conclusion Compared with signle high dose of gamma globulin ,high dose of gamma globulin combined with methylprednisolone in acute Guillain-Barre syndrome decreases the hospital time for its safety ,rapid action and little adverse re-actions.
出处
《中国实用神经疾病杂志》
2014年第9期28-29,共2页
Chinese Journal of Practical Nervous Diseases
