摘要
目的评价治疗性血浆置换(TPE)治疗吉兰巴雷综合征(GBS)的临床疗效和安全性。方法回顾性分析比较本院神经内科和ICU 26例GBS患者进行基础治疗的同时进行TPE前后肌力变化,结合相关常规指标和生化指标,评估TPE的疗效,并同时观察TPE的副反应。结果采取TPE后患者肌力平均评分高于治疗前,差异有统计学意义(P<0.05),全部患者临床症状均有一定程度改善,治愈率88.46%,总有效率100%。TPE相关副反应表现为轻度寒战、皮肤瘙痒、皮疹等过敏现象,低血糖,发生率为7.5%。结论 TPE能够改善GBS患者相关症状,疗效肯定且副反应少,其治疗基本安全有效,值得临床进一步推广应用。
Objective To evaluate the, efficacy and safety of therapeutic plasma exchangc （TPE） in Guillain-Barre syndrome （GBS）. Methods 26 patients with GBS were retrospectively selected from the department neurology and ICU of The Third Xiangya Hospital of Central South University, and analyzed the changes of myodynamia before and after basic treatment,and observed biochemical indicators to assess the efficacy and the side effects of TPE. Results The score of myodynamia had significantly elevated after TPE （ P 〈 0. 05）. The clinical symptoms of all patients were relieved by TPE. TPE-related side-effects included mild chills,itching,rashes and other allergic phenomena. Conclusion TPE can improve symptoms in patients with GBS,and provides a novel therapy approaches for patients with GBS.
出处
《中国输血杂志》
CAS
CSCD
北大核心
2014年第1期48-50,共3页
Chinese Journal of Blood Transfusion
关键词
吉兰巴雷综合征
血浆置换术
肌力
Guillaink-Barre syndrome
plasmapheresis
myodynamia
